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Integral of Pain Relief as an Innovative Method of Pain Measurement
Objective: To describe and bring awareness for the Integral of Pain Relief (IPR), a novel multidimensional measure which can be used by practitioners in daily practice. Methods: The IPR incorporates both a patients’ percentage of pain relief since treatment, along with their duration of relief into a single, multidimensio.. Read More
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The literature on application of prolonged PRF of genicular nerves of knee for osteoarthritis of knee is nil. This study will provide level IV evidence that prolonged PRF is a safe and effective in treating knee pain from osteoarthritis of knee joint not responding to conservative modalities of treatment and who wants to avoid s.. Read More
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Topical Analgesics: Critical Issues Related to Formulation and Concentration
Topical analgesics are in need to be differentiated from transdermal formulations of analgesics. Topical analgesics are characterized by local analgesic effects in the absence of systemic effects, and do not require a transdermal delivery formulation. There are two key issues in the development of topical analgesics. 1. For opti.. Read More
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The Surgical Treatment of Trigeminal Neuralgia
Trigeminal Neuralgia is a clinical presentation of different diseases, defined in the last edition of the International Classification of Headache Disorders (ICHD-3) as “Classical Trigeminal Neuralgia” and “Painful Trigeminal Neuropathy”. In both groups typical and atypical clinical findings are present. .. Read More
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Postincisional Pain in Spinal Cord Stimulation: Incidence and Treatment
The post incisional pain is a biological complication of the spinal cord stimulation implantation. The frequency of this condition in literature reported studies ranges from 0.9% to 12%. The causes of this pain are unclear and there is no homogeneity in the reported data. The treatment of this surgical complication is not well e.. Read More
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Peripheral Nerve Stimulation in Refractory Neuropathic Low Back Pain
Introduction: Spinal cord stimulation is now a treatment of pain in refractory failed back surgery syndrome. The effect on radiculalgias is quite good but often unsatisfying to treat completely low back pain. Subcutaneous peripheral nerve stimulation is now one of the possibility to rescue chronic low back pain. The aim of this .. Read More
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Oxytocin is a peptide hormone released in our body. It plays a very well-known role in pregnancy-related uterine contractions and lactation. But oxytocin does a lot more than just helping women get through labour. Recent studies have shown that it contributes to pain perception and pain physiology. In this short article, we emph.. Read More
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Therapeutic efficacy of pregabalin (PGL) for reducing neuropathic pain in patients who received a cervical operation is unclear. The purpose of this prospective pilot study was to compare the efficacy and adverse events between PGL and acetaminophen (ACM) for residual neuropathic pain. Thirty-four patients who received cervical .. Read More
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Thinking Out of the Pillbox: The Relevance to Topiceuticals in the Treatment of Neuropathic Pain
Topiceuticals can be defined as specialized pharmaceutical formulations containing topically applied drugs. Topiceutical analgesics need to be differentiated from transdermal formulations of analgesics. The latter formulations are specially designed for the active pharmaceutical ingredient to penetrate all skin structures and to.. Read More
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Procedural Sedation and Analgesia in Emergency Department: A Review and Update
Procedural sedation and analgesia is one of the common clinical practices in the emergency department. The level of sedation must be adjusted in such a way that it allows patient to tolerate unpleasant procedures while maintaining normal physiologic reflexes and consciousness and able to understand and respond to verbal or light.. Read More
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Evaluating Chronic Pain Patients Using Methods from Johns Hopkins Hospital Physicians
Chronic pain patients are misdiagnosed 40%-80% of the time, according to research from Johns Hopkins Hospital physicians. Methods to determine the validity of the complaint of pain, as well as clinical suggestions on methods to improve the accuracy of diagnosis and testing are summarized, as well as the description of an Interne.. Read More
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Extraction and Comparative Analysis of Moisture and Capsaicin Contents of Capsicum Peppers
Capsaicin and moisture contents of three varieties of Capsicum peppers [Capsicum frutescens- Bird eye pepper (X1) and two varieties of Capsicum annum: Chilli pepper (X2) and sweet pepper (X3)] were determined and the level of pungency related to reported observed effects on human-beings especially, as a topical analgesic. Extrac.. Read More
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Objective: Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain associated with a variety of other symptoms. In order to evaluate the effects of a multimodal analgesia approach to the treatment of FMS, a retrospective observational study was performed. Methods: Sixty-nine consecutiv.. Read More
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Post Terbinafine Adrenal Gland and Testis Dysfunction that Imitated Fibromyalgia: Case Report
We present the case of a 35 year old patient who suffered from the chronic widespread pain that mimicked fibromyalgia or myopathy, and turned out to be an acquired endocrinological disorder. The Patient was previously treated for fungal skin infection and had been taking terbinafine for 3 months and developed testis and adrenal .. Read More
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Background: Surgery is usually the first treatment for breast cancer which is followed by some complications such as chronic pain. Post mastectomy pain syndrome (PMPS) is a common complication among breast cancer survivors and is considered as a chronic neuropathic pain in the side of surgery which persists more than six months... Read More
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Introduction: In 1953, Luft and Olivecrona described surgical ablation of the pituitary gland in the treatment of metastases from hormone-dependent tumors, with a view to reduce the spread of the disease rather than specifically for analgesia. The mechanism of hypophysectomy remains uncertain, but it has been suggested that part.. Read More
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Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats
Background: The barks of the medicinal plant, Terminalia brownii, are widely used in African folk medicine for the management of pain. However, this ethno-medicinal allegation has not been scientifically validated. This study was therefore designed to verify the antinociceptive potential of the methanolic bark extract of T. brow.. Read More
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A Review of Scrambler Therapy for Chronic Neuropathic Pain
Introduction: An increase in accidental death related to prescription opioid abuse prompts the identification of novel strategies to treat chronic pain at a low risk to patients and their communities. Scrambler therapy (ST) has recently emerged as a viable treatment option for patients with neuropathic pain (NP), prompting a sys.. Read More
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Introduction: Properly obtaining informed consent for spinal anesthesia is a skill expected of anesthesiology residents. The goals of the study were to 1) use a Delphi method to develop a curriculum for teaching informed consent for spinal anesthesia, and a checklist of required elements; 2) determine which elements of the infor.. Read More
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Pharmacological Interventions for Neuropathic Pain Associated with Compressive Myelopathy
Neuropathic pain following spinal cord injury (SCI) is a common problem in patients with SCI, which influences the quality of life of such patients. However, in our experiments of treatments for patients with compressive myelopathy, neuropathic pain was identified in patients with not only SCI, but also those with compressive my.. Read More
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