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Overview of Bone Tumours in a Tertiary Care Hospital
Background: The neoplasms of bone account for only 0.2%–0.5% of the overall human tumour biology. Most bone tumours arise de-novo from genetic mutations; but numerous risk factors such as chemotherapy, irradiation, foreign bodies, bone infarcts and pre-existing bone lesions have been implicated. Bone tumours have heterogen.. Read More
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Hemostasis with Woundclot Hemostatic Gauze in Orthopedic Oncology Surgery
The subspecialty of orthopedic oncology is concerned with the diagnosis and treatment of musculoskeletal tumors, both primary and secondary, both benign and malignant. Nearly 50 types of procedures, ranging from short biopsies to lengthy 12 hour hemi-pelvectomies, are performed by orthopedic oncologists. They can require signifi.. Read More
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A Sessile Solitary Osteochondroma in an Unusual Location
Introduction: Osteochondroma usually presents as a solitary or multiple forms, former presents in cases of hereditary multiple exostosis. Solitary Osteochondroma is a benign tumor which occurs generally in children and adolescents. We present a solitary sessile Osteochondroma in an unusual location and size. Case Study: A 14 yea.. Read More
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Introduction: Acute calcific tendonitis at the pectoralis major insertion is rarely reported in the radiology literature, but not in the Orthopaedic literature. We present a case that illustrates the typical findings with discussion from a shoulder surgeon, and a senior radiologist. Case Study: A 60-year-old woman was woken at .. Read More
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Autophagy as a Possible Target for Cancer Therapy
Autophagy is an evolutionarily conserved catabolic process that targets cellular organelles and cytoplasmic constituents to the lysosomes for degradation. According to the type of cargo delivery, there are three main types of autophagy systems in mammals: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroaut.. Read More
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Neoplastic Limp or Irritable Hip?
A child who has an acutely irritable hip with septic picture can pose a diagnostic challenge. Although neuroblastomas are rare in children, symptoms may substantially overlap in the acute setting makes differentiation difficult. In this case report we have outlined the importance of clinical and radiological findings in two case.. Read More
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Giant Cell Tumor in a Patient with Osteopetrosis: A Case Report
Introduction: Osteopetrosis, a rare disorder due to osteoclast dysfunction, which causes bone resorption dysfunction. These patients have brittle bones prone to osteomyelitis. Case presentation: A 14-years male referred with complaint of chronic low back pain. He was treated with analgesics but with no pain relief, thus i.. Read More
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Patellar Capillary Hemangioma in a Child âÃâ¬Ãâ Is Patellectomy Necessary?
Patellar capillary hemangioma is a very rare tumor with only a few reported cases in the medical literature. Previously, this tumor was treated by means of partial patellectomy. We treated a skeletally immature 13 years old boy with a painful capillary hemangioma by curettage, bone grafting and internal stabilization. C.. Read More
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Primary Lymphoma of Bone Literature Review
Primary Lymphoma of Bone (PLB) is a very rare neoplasm presenting most commonly with bone pain and swelling or as an incidental finding on imaging. PLB diagnosis requires tissue biopsy and Non-Hodgkin’s lymphoma (NHL) is the commonest sub-type. Disease staging includes thoracic-abdominal-pelvic computed tomography sc.. Read More
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Clinical Outcomes of Grade 3 Giant Cell Tumor of Bone After Extended Intralesional Curettage
Introduction: The recommended treatment of grade 3 giant cell tumor of bone (grade 3 GCTB) aims to eliminate tumor and conserve limb with extended intralesional curettage. This treatment makes patients better function of bone and joint as usual. Even it can reduce postoperative complications and replace endoprosthesis. Still, th.. Read More
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Multifocal Epithelioid Hemangioendothelioma
A case of a rare epithelioid hemangioendothelioma (EHE) with multifocal location in a 32 year-old male is reported. The patient presented to our hospital with a knee pain. After thorough investigations and establishing the diagnosis, surgical treatment was done. This tumor involves bones of the axial skeleton and long tubular bo.. Read More
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Cavernous hemangiomas, first described by Globus in 1929, are one of the uncommon vascular malformations of central nervous system. They seemed to have benign vascular structure with dilated vessel bed. Cavernous hemangiomas encompass nearly ‘five’–12% of all spinal vascular malformations; however, exis.. Read More
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Primary Cutaneous Ewing Sarcoma: Case Report and Review of Literature
Ewing sarcoma (ES) is a primitive neuroectodermal tumor. It’s usually a primary bone tumor but rarely occurs in the skin and subcutaneous tissues. Current literature reports only a few isolated cases or small series. To date, less than 100 cases have been reported. The diagnosis is made by aspiration cytology, histochemica.. Read More
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Giant Hidradenoma of Limbs: A Report of Two Pediatric Cases
Hidradenoma is a rare benign tumor that develops of the eccrine sweat glands. We report here two cases of benign giant hidradenoma with a clear cell variant in one case and nodular in the other. The tumor was localized on the forearm in a patient aged 6 years and in the foot in a 14-year-old child. An excisional biopsy was perfo.. Read More
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Aneurysmal bone cyst is a rare benign bone tumor usually treated by surgery, which may in turn result in poor functional outcome and recurrence. This study aims to report a series of cases of primary ABC treated with a single dose of calcitonin and methylprednisolone injection. Six patients treated with a single-dose combination.. Read More
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Primary Bone Lymphoma Mimicking as Osteomyelitis: An Unusual Presentation
Primary Bone Lymphoma is a rare disorder, even though secondary involvement of bone marrow in systemic Lymphoma is common. Most of Primary Bone Lymphomas are Primary Bone Diffuse Large B-cell Lymphomas. We describe a case of Primary Bone Lymphoma, initially treated as Osteomyelitis of unknown etiology. This case shows the diffic.. Read More
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Challenges with Big Data in Oncology
We are in the era of large-scale science. In oncology there is a huge volume of data sets grouping information on cancer genome, transciptome, clinical data and more. The challenge of big data in cancer is to integrate all this diversity of data collections into a unique platform that can be analyzed leading to the generation of.. Read More
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Large cell neuroendocrine carcinoma (LCNEC) is a rare, highly malignant neoplasm with a dismal prognosis. The majority of patients will present with metastatic disease with a median overall survival of 6 months for this group. We present a case of metastatic LCNEC to the pelvis with a 10 year survival after tumor resection, radi.. Read More
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Intranasal Diprospan Injection for Chronic Rhinosinusitis Treatment-Two Case Reports
Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects 0.5–4% of the world population and is present in ∼20% of patients with CRS. There are no definitive guidelines for the treatment of CRS largely due to the lack of consensus on the etiology of the disease. The management of chronic rhinosinusitis with nasal po.. Read More
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Objective: Limb-sparing surgery is the mainstay treatment for musculoskeletal tumors thanks to advances in surgical techniques, imaging modalities and multimodal therapies. As patients survive longer, plastic reconstructive procedures and revision surgery are increasingly required after tumor excision. Infection rate is reported.. Read More
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