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Analysis of Bone Histomorphometric and Microarchitecture in Patients with Metastatic Bone Cancer
The in vivo effects of potent bone-targeting agents (BTAs) on bone homeostasis, bone quality, and bone architecture are poorly understood, despite their widespread use in oncology patients. Traditionally, a trans-iliac bone biopsy with a 7 mm “Bordier” core needle was used to evaluate bone quality. As a more practica.. Read More
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A Review on Primary Bone Tumor: Considerations for Treatment-Induced Complications
It is critical to identify a benign primary osseous tumor because adult and pediatric patients present with distinct symptoms. A neoplasm that is curable may progress into a lethal one with the wrong treatment, resulting in patient morbidity and mortality. Understanding the subtype of tumor and whether it is a malignant or benig.. Read More
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A Case Report on Bone Tumor: Osteosarcoma of the Maxilla of Mixed Type
Osteosarcoma (OS), which accounts for approximately 20% of all primary bone cancers, is the most prevalent primary malignant bone tumor. OS affects 2-4.8 out of 1,000,000 people annually and is more common in men (1.5:1) than in women. The femur (42%) is the most common site, followed by the tibia (19%), the humerus (10%), and t.. Read More
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Aneurysmal Bone Cyst of Calcaneum â A Rare Case Report
Introduction: Aneurysmal Bone Cyst is a benign reactive bone lesion filled with multiple blood-filled cavities, locally destructive and expansile lesion. The incidence of Aneurysmal Bone Cyst in tarsal bone is less than 12% of which calcaneum account for about 1.6% of all Aneurysmal Bone Cysts. Here, we report a case of Aneurysm.. Read More
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Short Review on Doxorubicin Treatment Stabilizes Metastatic Bone Cancer
In breast cancer, complete bone marrow infiltration accompanied by severe pancytopenia is extremely uncommon. After metastatic breast cancer develops, bone marrow metastasis may frequently occur. However, it is uncommon to observe bone marrow failure as a sign of this disease. The safest and most effective way to treat patients .. Read More
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Optimizing the Life Quality of Tumor Symptomatic Patients: Emphasis on Metastatic Bone Cancer
Skeletal complications are frequently linked to patients with advanced cancer who have metastatic bone disease. These can be crippling, resulting in pain, reduced quality of life, and decreased survival rates. This review looks at ways to minimize the significant burden that metastatic bone pain can place on affected patients by.. Read More
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Brief Discussion on Metastatic Bone Osteolysis
Bone-resorbing osteoclast activation facilitates breast and prostate carcinoma bone metastasis. We have identified peroxiredoxin-4 (PRDX4) as a mediator of osteoclast genesis that is released by cancer cells through proteomics methods. Using immunoblotting and mass spectrometry, we now report the characterization of L-plastin in.. Read More
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Oncological and Functional Outcome in a Rare Case of Clear Cell Chondrosarcoma of the Proximal Femur
Chondrosarcomas are the second most common bone sarcomas, accounting for less than 0.5% of all cancers. The treatment plan can be improved by analyzing clinical characteristics and treatment patterns. The rarity and slowgrowing nature of this tumour often lead to prolonged symptoms and also initial misdiagnosis with avascular ne.. Read More
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Recurrent Pelvic Aneurysmal Bone Cyst Treated With Doxycycline: A Case Report
Background: Aneurysmal bone cysts (ABCs) are locally aggressive, non-cancerous bone lesions that are rare, most commonly occur in children (75% of patients are < 20 yrs 1), and typically continue to spread until treated. They have a high risk of recurrence [1]. Methods: We present an 11-year-old female with a recurrent ABC o.. Read More
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Osteocartilaginous Exostosis: Types and Symptoms
A subungual exostosis (SE) is a bony overgrowth that is permanently attached to the tip of the distal phalanx. Its pathology differs from osteocartilaginous exostoses in that it mainly involves the overgrowth of normal bone, which may present beneath the toenail or on the sides of the toe. This retrospective study aimed to repor.. Read More
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Symptoms and Treatment of Aneurysmal Bone Cyst
Aneurysmal bone cysts are benign tumors with potential for aggressive behaviour and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear.. Read More
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Multilobular Tumour of Bone and Classification
A seven-year-old neutered female golden retriever was presented for an acute onset of cervical pain and ataxia. Intervertebral disc disease or neoplasia was suspected. There was no evidence of a soft tissue or bony mass on physical examination or survey radiographs. Cerebrospinal fluid analysis did not show any evidence of a neo.. Read More
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Glucosamine and Symptomatic Effects Osteoarthritis
Over the last 20 years, several studies have investigated the ability of glucosamine sulfate (GS) to improve the symptoms (pain and dysfunction) and delay the structural progression of osteoarthritis. There is now a large, convergent body of evidence that glucosamine sulfate, given at a daily oral dose of 1,500 mg, significantly.. Read More
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Extra-Thoracic Solitary Fibrous Tumours: Outcomes and Prognosis
Introduction: Solitary fibrous tumours (SFTs) are rare spindle cell neoplasms and have been described according to location as intra-thoracic and extra-thoracic. The World Health Organization classifies SFT as having intermediate malignant potential with low risk of metastasis. Initially extra-thoracic SFTs (ESFT) were considere.. Read More
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Rhabdomyosarcoma and Its Risk Factors in Adults
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma and represents a high-grade neoplasm of skeletal myoblast-like cells. A gradual improvement in understanding of physiology has helped optimize clinical care. Two main subtypes of RMS. Originally characterized by features of optical microscopy. Driven by fundamentally diff.. Read More
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Management of Soft Tissue Sarcoma after Microsurgery
Sarcoma is a tumor of mesenchymal origin with great variation in anatomical location. Sarcoma affecting bone often requires an interdisciplinary approach to resection and reconstruction. However, as limb salvage is only a secondary goal of tumor surgery, it is important that micro reconstruction strategies do not adversely affec.. Read More
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Malignant Transformation of Osteoblastoma of the Capitate: A Case Report
Osteoblastoma is classically described as a more aggressive form benign bone forming tumors that mainly occurs in the axial skeleton and spine. There have been few case reports and case series of this lesion occurring in the carpal ones, and only three reported cases occurring in the capitate, which were all treated successfully.. Read More
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Nanotechnology: Novel Approach in Orthopedic Oncology
Malignant neoplasms represent a genuine public medical condition in the modern world. Assessments from the GLOBOCAN project show that in the year 2015 rate and mortality extends an overall frequency of over 15.2 million new instances of malignancy, and deaths of over 8.8 million. Musculoskeletal tumors are moderately uncommon, a.. Read More
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Secondary Sarcomas Associated with Bone InfarctâThe Birmingham Experience
The majority of primary bone sarcomas arise de novo, however some develop in association with bone infarction and are only sparsely reported in the literature. The objective of this study was to investigate the 14 cases of secondary sarcoma associated with bone infarct presenting at a single tertiary referral centre at the Royal.. Read More
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Osteosarcoma and its Symptoms in Childrenâs
Osteosarcoma (OS), the most common type of primary malignant bone tumor, is defined by the presence of malignant mesenchymal cells that produce osteoid or immature bone. The highest incidence of the most common types of OS, high-grade central OS occurs in the 20th year of adolescent fast-growing life. Most patients experience pa.. Read More
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