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Nodular Hidradenoma Mimicking Breast Cancer: Diagnostic Conundrum
A nodular hidradenoma, clear cell hidradenoma or eccrine acrospiroma is an exceedingly rare entity in the breast tissue. It is a benign adnexal cell tumor derived from eccrine sweat gland. To our knowledge approximately thirty cases are reported in English literature. The aim of this article is to raise the awareness of this tu.. Read More
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Use of RPMI in Vitreous Cytology: The Case for Sterile, Single Use Aliquots
Importance: Sterile aliquots of Roswell Park Memorial Institute (RPMI) are necessary in obtaining uncontaminated vitreous biopsies. Background: To report a case of RPMI medium contamination in diagnostic pars plana vitrectomy (PPV) to exclude vitreoretinal lymphoma. Design: Interventional case report. Participants: One patien.. Read More
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Mitochondrial ABC Transporters and Iron Metabolism
Mitochondrial are a key organelle in iron metabolism and many metabolic processes involved in iron homeostasis occur in the mitochondria. Eukaryotic cells have developed different transport mechanisms to deal with coordinating movement of iron and iron-related molecules across membranes. Some of those transport mechanisms involv.. Read More
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Acromegaly: Current Challenges and Future Directions in Latin America
Acromegaly is a rare disease, associated with significant morbidity and high mortality. The international literature provides different figures on the epidemiology of acromegaly in different populations, mainly in Europe and US. However, there are few studies that address its epidemiology in Latin America. The creation, starting.. Read More
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Objective: A number of studies compare the microarray normalization methods MAS5 (Microarray Suite Version 5), RMA (Robust Multi-array Average) and PLIER (Probe Logarithmic Error Intensity Estimate) with respect to the rate at which genes of interest are identified. Here we evaluate and compare the stability of the measured gene.. Read More
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H2AX is required for genome stability. In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated to form γH2AX foci, which mediate DNA repair and checkpoint signaling. This process is regulated by modifications and molecular interactions of H2AX. In addition, the rapid stabilization of H2AX in response .. Read More
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Mitochondrial Dysfunction Signature in Diabetic Vascular Endothelium
Mitochondrial dysfunction/malfunction is an important risk factor for the onset and progression of endothelial cells dysfunction, a key contributor to diabetes mellitus associated cardiovascular disease. The topics discussed here are: (i) The regulatory role of mitochondrial ROS in normal, healthy vascular endothelium, (ii) The .. Read More
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Objective: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a generalized vasculopathy caused by mutations in the NOTCH3 gene, leading to degeneration and loss of vascular smooth muscle cells (VSMC). The relationship between NOTCH 3 mutations and VSMC death is unknown. One p.. Read More
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Smoking has been involved as a significant risk factor for series and establishment of diseases. The aim of our study to investigate smoking effects induced oxidative damage. We have chosen male students of Al-Iraqia University and Tikrit University, aged 20-23 years. In our study we measured activity of Lactate Dehydrogenase (L.. Read More
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Soft Tissue Rosai-Dorfman Disease with Unusual Histopathologic Features: A Case Report
Rosai-Dorfman disease is a rare proliferative histiocytic disorder of unknown etiology. It is a unique disorder of the lymph nodes but extranodal sites such as bone, skin, central nervous system, upper respiratory tract and soft tissue may be affected. Rosai-Dorfman disease is presented with massive, symmetrical cervical lymphad.. Read More
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Leiomyomatosis Peritonealis Disseminate Following Laparoscopic Myomectomy with Power Morcellation
Background: Leiomyomatosis peritonealis disseminate (LPD) is a rare benign entity, but its histological origin remains unclear. Cases: An unusual DPL case which was diagnosed at 4 years after her initial laparoscopic uterine myomectomy with power morcellation, and recurred 4 years later. The findings during the exploratory lapa.. Read More
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Analysis of Platelet Count in Patients with Bleeding Gums
Aim: The aim of this study is to analyze the platelet count of patients with bleeding gums. Material and methods: 50 patients who reported to Saveetha Dental College with a chief complaint of bleeding gums were assessed for their platelet count to find any relationship of bleeding with platelet count. Reason: Platelets play an.. Read More
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Orofacial Cysticercosis: A Review
Cysticercosis is a common healthcare problem, especially in developing countries. Orofacial presentation of the disease is rare. It usually manifest as an asymptomatic nodular swelling that is difficult to differentiate clinically, from other orofacial swellings. Diagnosis of cysticercosis is usually not possible clinically owin.. Read More
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Objective: To determine the variations in thyroid hormones, thyroid stimulating hormone and prolactin levels in females of our population. Materials and methods: Subject characteristics: Patients aged 13 to 60 years were studied for their hormonal profile. The inclusion criteria had patients with complaints of mild reproductiv.. Read More
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Role of metalloproteases and adhesion molecules has been studied in cancer and metastases; tyrosine kinase receptors (TKRs) and mucins are related to their expression. Objective: To investigate the effects of MUC1/c-Met, and their participation in metastatic mechanism in head and neck carcinoma cell lines. Materials and method.. Read More
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Biological Features of IL-12 and IFN-Îó in the Pathogenesis of Systematic Lupus Erythematosus
Systemic lupus erythematosus is a chronic autoimmune disease characterized by abnormal immune response with overproduction of auto-antibodies, self-destructive complexes and hyperactivity of both T and B lymphocytes. Although the exact pathogenesis of SLE remains unclear, it has been found that the imbalance of Th1/Th2, subsequ.. Read More
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Isolations and Cultures of Primary Hepatocytes
Various liver diseases result in liver failure, and liver transplantation and artificial liver support systems are emerging as alternative therapies for these disease. However, both treatments are depending on cell resources, so isolating sufficient number of functional primary hepatocytes is a most important early issue. Isolat.. Read More
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A Clinicopathological Study of cd34 Antigen Expression in Benign and Malignant Breast Lesions
Objectives: To study stromal CD34 expression in benign and malignant breast lesions and evaluate whether loss of CD34 is specific for invasive disease. Material and methods: 317 cases of benign and malignant breast lesions were studied over a period of 2 years (July 2012 to June 2014). All the cases underwent routine proces.. Read More
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Gastric Synchronous Stromal Tumor and Adenocarcinoma: A Fortuitous Association?
The association of an adenocarcinoma with a stromal tumor in the stomach is rarely observed. We report the observation of a patient operated for a synchronous tumor associating subcardial adenocarcinoma with a stromal tumor of the gastric body. It is a 74 year-old patient, diabetic, who was admitted, in December 2016, for ep.. Read More
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Electrical membrane breakdown (EMB) is a novel form of non-thermal treatment that has not, to our knowledge, been previously evaluated for its potential utility as an ablation mechanism. The findings with EMB immediately after treatment were compared with other forms of ablation (cryoablation and IRE (irreversible electropor.. Read More
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