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A Patient with Glucophage-Induced Sexual Dysfunction: Case Presentation and Review of the Literature
Background: Attention to Glucophage induced impotence has attracted the attention of doctors. Optimal drugs for diabetes maximize therapeutic response and minimize adverse effects. Sexual activities in diabetes might decrease because of medications or sickness. So far there are no report to show the possible adverse effect of Gl.. Read More
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Valproate Level Variation with Menstrual Cycle Phase in Bipolar Disorder
Objectives: The purpose of this study was to investigate the changes in serum valproate (VPA) levels and their relationship to progesterone levels during the menstrual cycles of fertile women. Materials and methods: Female patients compliant with VPA (n=14) were included in this study. Serum VPA and progesterone levels were mea.. Read More
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Several studies have demonstrated the dysregulation of miR-449b-5p in numerous types of human cancers. However, the understanding of the function of miR-449b-5p the mechanisms linking its expression to the development of colorectal cancer (CRC) remains limited. The current work documented the decrease in the level of miR-449b-5p.. Read More
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Platelet Parameters and Variations with Age amongst Elderly Nepalese Presenting in Bpkihs, Dharan
Purpose: The purpose of this study was to calculate normal range of platelet count and to find relationship of platelet count and MPV with age and sex. Methods: Prospective study was done on 202 people visiting haematology department of BPKIHS, 100 as cases and 102 as controls. Platelet counts and MPV was measured by 5-part hae.. Read More
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Invasive Ductal Breast Carcinoma in an 18-Year-Old Woman: A Casual Misfortune?
Malignant Breast Cancer is a life-threatening condition, with wide-world growing impact. The incidence of neoplastic malignant breast disease is showing a shifting paradigm, occurring overtime in younger ages. The authors report a case of an eighteen year-old Caucasian woman complaining with an induration in her left breast for .. Read More
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The Role of Micronuclei as a Screening Tool in Oral Cancers
Background: The assessment of Micronuclei frequency in exfoliated oral epithelial cells has been shown to correlate with severity of the chromosomal damage and seems to increase steadily in malignant lesions. Aim: To evaluate the frequency of micronuclei (MN) in oral exfoliated cells of malignant oral lesions in tobacco chewers.. Read More
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Blastoid Mantle Cell Variant of Richter’s Transformation
An unusual occurrence of blastoid variant of mantle cell lymphoma arising in a patient with untreated chronic lymphocytic leukemia/small lymphocytic lymphoma is described. A localized site of intense uptake on positron emission tomography suggested Richter's transformation. Biopsy of the suspect area showed the blastoid variant .. Read More
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Nivolumab Bullous Pemphigoid: Case Description and Literature Review
Nivolumab is a monoclonal antibody, belonging to the checkpoint inhibitors, recently approved for treatment of recurrent or metastatic non-small cell lung cancer, melanoma, and renal cell carcinoma. Although very efficacious, oncologic immunotherapy is associated with a new spectrum of dermatological adverse events, and spontane.. Read More
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Previous researches have shown that anxiety symptoms are negatively associated with measures of intelligence. However, recent findings indicate possible positive relationships between generalized anxiety disorders, worry, rumination, post event processing and intelligence. The present study examined the relationships between GAD.. Read More
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Objective: An insertion/deletion polymorphism in the Angiotensin Converting Enzyme (ACE) gene has been implicated in the pathogenesis of heart disease. The present cross sectional study evaluated the ACE gene I/D polymorphism in an urban worksite cohort. Method: Fasting blood samples from 132 subjects from a worksite in Mumbai.. Read More
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Management Outcome of Small Intestinal Obstruction in Mizan Aman General Hospital, Ethiopia.
Background: Small Intestinal obstruction is defined as any hindrance to the passage of small intestinal contents. It is one of the most common causes of acute abdomen. If not treated on timely manner the outcome will be bad. The causes are varying from region to region, as well as from season to season. Knowing this variety help.. Read More
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Diagnosis of anogenital infections by Chlamydia trachomatis is challenging, because symptoms are mild, nonspecific and tolerated long time by patients before seeking the clinician. When diagnostic attempts are done, empiric treatment of symptoms modifies clinical presentation to such an extent that it is likely to incur a misdia.. Read More
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Phantageusia and its Inhibition by Repetitive Transcranial Magnetic Stimulation
Background: Phantageusia is an unpleasant, commonly persistent oral taste occurring without any oral stimulus. It is commonly experienced by patients subsequent to loss of taste acuity (hypogeusia). There is currently no defined treatment. We wished to describe phantageusia and efficacy of its treatment with repetitive transcran.. Read More
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Clinical Effectiveness of Routine Pathological Exam after Bariatric Laparoscopic Sleeve Gastrectomy
Aim: To evaluate the clinical effectiveness of routine pathology exam as a diagnostic tool after laparoscopic gastric sleeve.Method: A review of diagnostics coming from 347 bariatric gastric specimens sampled over four years.Results: Only 6.3% of histology diagnostics were labelled as “normal”; “chronic gastrit.. Read More
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Background: Dental disease following chemotherapy and radiotherapy is a common and important problem in many head and neck cancer patientsAim: To compare the complications and oral health status of patients who received radiotherapy with those who received chemotherapy.Methods: A cross-sectional study was conducted in the Oncolo.. Read More
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Scientific Interest on Cardiovascular Health and Cardio Rehabilitation.
Introduction: The prescription of physical exercises must be adjusted in the proportion in that the cardiovascular capacitating and the physical capacitating for the diary activities were going better according to rehabilitation program proposed by physiotherapy. It verified the number of publications in indexed journals cited o.. Read More
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An Epithelioid Sarcoma of the Right Foot: Raising Awareness of a HighGrade Malignancy
An epithelioid sarcoma (ES) is an infrequent mesenchymal malignancy most commonly encountered in adolescents and young adults in the distal extremities. It has a proclivity for the flexor aspects of the hands and feet with male predilection observed at a ratio of 2:1. The indolent presentation, seemingly unremarkable histopathol.. Read More
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Introduction: Tissue processing using xylene/chloroform has been employed in histopathology reporting for the past 100 years. Microwave technique has not only reduced the processing time from 1 day to one hour but also doesn’t use xylene/chloroform and has been found to be on par with conventional processing. Xylene is exp.. Read More
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Here we investigate hematological and biochemical alterations in the burn animals. The values of these parameters are very important in allowing the veterinarians to know how the animal body is responding to the different therapies that being provided? And this will help the veterinary medical staff for proper management with le.. Read More
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Role of BRCA1 and PARP1 has been studied by immunohistochemistry in a cohort of ovarian cancers. Their expression has been related to overall survival and disease free disease. Objective: To investigate the clinical outcome of an heterogeneous population of ovarian cancers as respect to immunohistochemical expression of BRCA1 a.. Read More
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