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Primary Adenocarcinoma of the Bulbomembranous Urethra: Cause or Coincidence?
A 73-year-old male patient was followed in our urology department after prostate cancer in 2004 and bladder cancer in 2011. In April 2013, during the last cystoscopy, a bulbomembranous stricture was found and an urethrotomy was easily performed. Shortly after the procedure, the patient starts complaining of urinary dysfunction a.. Read More
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Morphological Features of Wilms Tumour in a Tertiary Health Care Institution: Our Findings
Nephroblastoma or Wilms’ tumour is the most common primary renal malignancy of childhood. Despite being a malignant tumour, a survival rate of over 90% is now seen today (compared to 30% in the thirties) and this resulted from the success of collaborative trials and the use of multimodal therapy. Black children have a 2... Read More
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Background: Salivary gland tumours comprise a significant proportion of oral tumours and are the next common neoplasm of the mouth after squamous cell carcinoma. These neoplasm’s have widely variable histopathologic and biologic characteristics, which makes it difficult to determine the pathogenesis and selection of therap.. Read More
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Chronic Prenatal Ethanol Exposure Disrupts WNT Signaling In Adolescent Cerebella
Background: In Fetal Alcohol Spectrum Disorder (FASD), structural and functional abnormalities in the cerebellum persist through adolescence and beyond. We hypothesize that perturbations in Wnt signaling may contribute to these effects because Wnt pathways mediate neuronal morphogenesis, migration, and plasticity during developm.. Read More
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Personalized Approach to Diagnosis and Treatment of Acute Myeloid Leukemia
Recent advances in disease pathogenesis and modern technologies are gradually transforming conventional medicine into personalized medicine. The personalized approach to diagnosis of leukemic patients consists of comprehensive and individualized evaluation based on characteristics of the tumor cell morphology, immunophenotype,cy.. Read More
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The article, “Dual mechanisms of ethanol-impaired placentation: experimental model”, by Drs.Gundogan et al. [1] utilized a robust experimental model of gestation alcohol exposures in rats to examine effects on placentation and fetal development. Dr. Gundogan et al. have pioneered a new field demonstrating the contrib.. Read More
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Dual Mechanisms of Ethanol-Impaired Placentation: Experimental Mode
Background: One of the major adverse effects of maternal ethanol consumption is intrauterine growth restriction (IUGR). Previous studies demonstrated that ethanol-induced IUGR is mediated by impaired placentation. Chronic gestational ethanol exposure reduces trophoblastic cell motility and invasiveness through inhibition of insu.. Read More
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Background: Hepatitis B virus (HBV) genotype C is associated with the development of Hepato Cellular Carcinoma (HCC). In addition, HBV subgenotype C1 is the major subgenotype in Southern China. The aim of this study was to investigate whether there was the specific mutation patterns in HBV/C1 associated with Southern Chinese pat.. Read More
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Emergence and dissemination of antibiotic resistance plasmids are major concern for hospital care system and increases the cost and decreases effectiveness of available antibiotics used in treatment of hospitalized patients. In this study two Pseudomonas aeruginosa, two Escherichia coli, and a Klebsiella pneumoniae were isolated.. Read More
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Study of Biochemical Risk Factors Involved in the Pathogenesis of Goiter in Adults in Sindh
Background: Deficiencies of iodine, Selenium, are the 2 most common micronutrient deficiencies in some areas of Pakistan, although control programs, when properly implemented, can be effective. Objective: We investigate these deficiencies and their possible interaction in adult age in both gendersof Hyderabad & plane areas .. Read More
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A Brief Review of the Controversial Role of Iron in Colorectal Carcinogenesis
Colorectal Cancer (CRC) is the second and third most common cancer in females and males worldwide, respectively. Major risk factors have been established for the development of CRC. These include susceptible genetics, increased age (50 years), male gender, and race. The role of environmental factors in CRC pathogenesis is ev.. Read More
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How long should Adjuvant Chemotherapy be given in Early Stage Colon Cancer?
After diagnosis of colon cancer, the tumor is removed and the stage of the disease is provided by a pathologist. If the stage indicates relatively high risk of relapse, adjuvant chemotherapy is used for 6 or so months to reduce the probability of such relapse. This is a very common situation in oncology – used for many e.. Read More
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Gastrointestinal stromal tumor is an uncommon tumor with most of these lesions occurring in the stomach. Patients present with nonspecific symptoms including bleeding, abdominal pain, and abdominal mass. The diagnosis of this tumor is made using various imaging modalities (CT, MRI and endoscopic ultrasound) and sampling techn.. Read More
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HIV is a retrovirus, but differs from other retroviruses such as Human T Lymphotrophic Viruses (HTLV) 1 and 2, is transmitted sexually and pre-natally. A total of eighty HIV/AIDS patients attending heart to heart in a Federal Medical center were assayed for the presence of Calcium, Magnesium and inorganic Phosphates which are am.. Read More
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Abstract Study background: Hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC), however, the mechanism of hepatocarcinogenesis in HCV infection is still undefined. Chemokines, which induce leukocyte migration and activate inflammatory/immune responses, have recently been implic.. Read More
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Detection and Epidemiology of Tick-Borne Pathogens in Free-Ranging Livestock in Mongolia
Abstract A cross-sectional epidemiologic investigation was undertaken to identify tick-borne pathogens in Mongolian livestock across two provinces (aimags) from 2007 to 2008. Serology and PCR were used to identify exposure to and infection with Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, A. ovis, and spotted f.. Read More
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Candidaemia in Immune-Compromised Hosts: Incidence and Drugs Susceptibility
Abstract We analyzed the different Candidae species isolated from bloodstream infections and the related antifungal susceptibility pattern over a five-year period (2007-2011) at Policlinico Umberto I of Rome (Italy). The overall incidence of candidaemia during this range of time accounted for 6.4% with a marked increase from .. Read More
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Abstract Epidemiologic studies have linked dioxins exposure to ischemic heart disease induced mortality. This study aimed to investigate the effect of subchronic combined exposure to tetra chloro dibenzodioxin (TCDD) and dibenzofuran (DF) on left ventricular myocardium of male rats; and the possible underlying mechanism. More.. Read More
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Abstract The health effects of the Municipal Auto-Battery Dust Leachate (MABDL) and Elewi Odo Municipal Auto- Battery Recycling Site Leachate (EOMABRL) on levels of Thiobarbituric Acid Reactive Substances (TBARS) were investigated in livers, kidneys and hearts of male albino rat-in vitro. The two varieties of leachates signif.. Read More
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Abstract Microarray gene expression profiling of frozen samples has identified Indicator genes predictive outcome in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) and there is a now a need to translate these to use in routine clinical material. In order to evaluate the use of Indicator genes as a diagnost.. Read More
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