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XB130 Expression in Human Osteosarcoma: A Clinical and Experimental Study
Identifying prognostic factors for osteosarcoma (OS) aids in the selection of patients who require more aggressive management. XB130 is a newly characterized adaptor protein that was reported to be to be a prognostic factor of certain tumor types. However, the association between XB130 expression and the prognosis of OS remains .. Read More
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Objectives: The significance of clonal evolution and derivative chromosome 9 in Philadelphia-positive CML is not fully characterized and studies have yielded conflicting results. After working on emergence of clonal evolution from our region, we continued to find out the response of Imatinib Mesylate on such cases of CML treated.. Read More
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Salivary duct carcinoma (SDC) is a malignant epithelial tumor extremely rare in minor salivary glands. This manuscript describes two cases of SDC of the minor salivary glands with different clinical behaviors. The first patient was an 80-year-old man who had SDC (T1N0M0) in the upper buccal fornix and the second patient was a 64.. Read More
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Oral Pigmented Lesions as a Consequence of the Human Papillomavirus
Our research is based on oral cavity pigmentation caused by melanocytes. From my medical experience, pigmented lesions may originate from endogenous or exogenous causes. It is a known fact that human papilloma virus is a type of virus that has more than 100 species that is likely to develop cervical cancer. They manifest in vari.. Read More
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Circadian Rhythm in Stroke: The Influence of Our Internal Cellular Clock on Cerebrovascular Events
The distinct temporal pattern of stroke occurrence in humans has been recognized for decades; yet, the reason underlying the temporal nature of stroke is not completely understood. Several exogenous factors such as seasonal variation, physical activity, diet and sleep/wake cycles can influence stroke occurrence. Furthermore, it .. Read More
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Several studies have shown Secreted Clusterin (sCLU) silencing directed against sCLU mRNA in sCLU-rich lung cancer cell lines sensitized cells to chemotherapy. However, the molecular mechanisms underlying the effect of sCLU silencing on lung cancer cell chemosensitivity is not known. In the present study, we aimed to determine t.. Read More
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Oral Rhabdomyosarcoma: A Case Report
Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm of skeletal muscle origin. The most common sites of occurrence are the head and neck, genitourinary tract, and extremities. Although Rhabdomyosarcoma has a relative predominance for head and neck region, it is less frequent in oral cavity, and accounts for only 0.04% of .. Read More
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Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology
Introduction: Isotretinoin is the mainstay therapy for severe and nodulocystic acne. Myalgia and muscle stiffness have been reported in 16-51% of patients treated with isotretinoin, while elevated serum Creatine Kinase (CK) levels have been found in up to 41%. In this paper, we report, for the first time, the occurrence of myopa.. Read More
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Epithelioid Hemangioendothelioma of the Rib: A Rare Tumour with a Confusing Localization
Background: Epithelioid hemangioendothelioma is a rare tumour whose prognosis ranges from benign form similar to hemangioma to aggressive tumors like angiosarcoma. Its localization in the rib is very rare and less than 10 cases of costal localized forms have been reported in the literature. The authors describe another case of c.. Read More
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Rheumatoid arthritis is a systemic, chronic inflammatory autoimmune disease affecting many tissues but principally attacking the joints. Auto antibodies such as rheumatoid factor and anti-cyclic Citrullinated peptide antibodies have important diagnostic value. This cross-sectional analytical study was performed at a single medic.. Read More
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Idiopathic Granulomatous Mastitis, a Clinicopathological Review of 22 Cases
Background: Idiopathic granulomatous mastitis is a rare chronic inflammatory disease and typically occurs in women at the reproductive life. The etiology, clinical course, and optimal treatment of this disorder remain obscure. The most common clinical presentation is a unilateral, firm, discrete breast mass, often associated wit.. Read More
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Pure primary Signet-Ring Cell Carcinoma (SRCC) of lung is an extremely rare entity. Typically seen in nonsmokers, it is considered to be highly invasive, highly aggressive and carries a worse prognosis when compared to other types of lung tumors. Cytological identification of pulmonary SRCC is challenging and must be differentia.. Read More
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We report that PiPE, a Phytophthora-associated PAMPS (Pathogen Associated Molecular Patterns), induced generation of active oxygen species and hypersensitive cell death (HR) by treatment of potato tuber tissues, and that the PiPE gene from a species of Oomycete, Phytophthora infestans Mont (de Bary), was cloned. Interaction of a.. Read More
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Papillary Thyroid Carcinoma (PTC) with prominent hobnail features is a recently recognized aggressive variant of PTC. The cytologic features and molecular characterization have not been fully investigated. We present a patient with a preoperative fine needle aspiration diagnosis of PTC with hobnail features that demonstrated con.. Read More
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Bacterial Lipopolysaccharide (LPS) is a glycolipid component of the cell wall of Gram-negative bacteria and is an endotoxin implicated in triggering sepsis and septic shock. Sepsis and its sequelae represent a continuum of clinical syndrome encompassing systemic inflammation, coagulopathy, abnormalities of the renal, hepatic, pu.. Read More
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Secondary Haemophagocytosis in a Patient with Ewing's Sarcoma
Secondary haemophagocytosis in malignant tumours have been reported in bone marrow. However we present engulfment of malignant apoptotic Ewing’s sarcoma cells by macrophages in the bone marrow. A 24 year old Pakistani male patient presented with complains of backache. After imaging, a laminectomy was performed the biopsy r.. Read More
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The body of a young black male suspected of stowing away in the wheel-well of a Lagos bound plane was found dead after it returned to Lagos from a flight to New York, United states. The body was reportedly discovered during a check on the aircraft panel as it was being prepared for another flight. There was no any means of ident.. Read More
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Renal Cell Carcinoma in Humans and Animals: A Brief Literature Review
Renal Cell Carcinoma (RCC) is the most common primary renal neoplasm in humans and domestic animals such as dogs, cats and horses. Various subtypes are recognized in both humans and animals. Advances in biomedical sciences have developed hitherto unprecedented extraordinary cancer therapeutic options varying from sophisticated s.. Read More
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Automated Versus Manual Platelet Count in Aden
This is a cross sectional study conducted in the National Center of Public Health Laboratories (NCPHL) of Aden – Yemen, during October-December 2011, with an overall aim to compare the results of platelet count by the automated versus the manual methods. Study included 190 random samples, examined with confirmatory plate.. Read More
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The Gastric Precancerous Cascade
Although most gastric cancers are first detected after the fifth decade of life, they represent the end product of a prolonged precancerous process initiated during childhood as a consequence of the infection of the mucosa with Helicobacter pylori. The initial phase of the process consists of active non-atrophic gastritis. The f.. Read More
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