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The Function Profiling of TIPE2 Reveals Links to its Potential Application
TIPE2, TNF-α-induced protein 8-like 2 (TNFAIP8L2), is a newly identified member of the TNFAIP8 family. Recent studies revealed that TIPE2 is a negative regulator of inflammation and carcinogenesis. TIPE2 deletion in mice causes fatal inflammation and its dysregulation in humans is associated with diseases, such as viral he.. Read More
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Human angiosarcoma (AS) is an infrequent soft tissue malignancy that may be difficult to diagnose, especially the solid, epithelioid or pleomorphic variant. A broad panel of antibodies is often necessary to determine the phenotype by Immunohistochemistry (IHC). To improve our knowledge of the morphology, immunophenotype, genetic.. Read More
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A 70 year old female underwent a hysterectomy due to a diagnosis of high grade endometrioid adenocarcinoma. Pathological examination revealed a Malignant Mixed Mullerian Tumor (MMMT) along with a conventional endometrioid adenocarcinoma with a component of giant cell carcinoma. Giant cell carcinoma of the endometrium is a rare t.. Read More
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Craniopharyngioma and Oil Machinery Fluid: Review
Craniopharyngiomas are non-glial epithelial tumors arising from the sellar/suprasellar region. They account for less to 4% of all intracranial neoplasms and for 5-10% of intracranial tumours in children. Are considered as benign tumors however, despite having a benign histologic appearance can turn to, invade, spread and have ma.. Read More
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Most infiltrative epithelial proliferations of the breast lacking a myoepithelial cell layer are malignant. The notable exception is Microglandular Adenosis (MGA). Lack of myoepithelial cells has also been noted occasionally in metaplastic apocrine glands. Here, we present a previously undescribed breast lesion that we have term.. Read More
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Extranodal Marginal Zone Lymphoma of mucosa-associated lymphoid tissue (ENMZL) is a problematic and sometimes controversial diagnosis. While commonly seen in the stomach in the setting of chronic Helicobacter pylori infection, other extranodal sites, such as the lung, may also present with disease. ENMZL is clinically and morpho.. Read More
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Expression of Erß and Bcl-2 in Skin Melanoma
Introduction: Skin melanoma has been one of the most researched malignant melanoma of today. Its "popularity" among the researchers and clinicians arises from variety of forms and biological behaviour, it's characteristic appearance, genetic and immunologic certainty and its prognostic uncertainty. Patients and method.. Read More
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Mesenchymal Stem Cells: How Can we Realize their Therapeutic Potential in Cancer Therapy?
Mesenchymal stem cells home to the tumour stroma from the bone marrow, influencing early tumour development and metastasis. Mesenchymal stem cells have been shown to be promising vehicles for cancer therapy due to this tropism for tumour sites, their immunoprivileged status, easy extraction from bone marrow and facile transfecti.. Read More
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Apoptosis-Biochemistry: A Mini Review
Apoptosis or programmed cell death is a normal component of the development and health of multicellular organisms. Homeostasis is maintained through a balance between cell proliferation and cell death. It is a process of controlled cellular death whereby the activation of specific death-signaling pathways leads to deletion of ce.. Read More
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Pattern and Distribution of Lymph Node Metastases in Papillary Thyroid Cancer
Background: The indications and extent of lymph node dissection in the treatment of papillary thyroid carcinoma remains controversial, and benefit from therapy is debatable. This study was designed to identify the pattern and distribution of lymph node metastases and to establish an optimal strategy for neck dissection for those.. Read More
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DNA-protection by Polyamines in Lactobacillus sakei No.2
In a previous study we showed that we had isolated Lactic Acid Bacteria (LAB) that produce high amounts of the polyamines found in fermented food that function as antioxidants . In this study, we concentrated on another function by investigating polyamines in relation to anti-cancer effects. Although a QR (Quinone Reductase) tes.. Read More
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Thoracic Myelolipoma: A Rare Case of Mistake in Lung Cancer Staging
Myelolipomas are benign tumors containing hematopoietic and fatty elements. They are commonly located in the retroperitoneum and mainly characterized by low density and low 18-FDG uptake on computed and positronemission tomography imaging. We report here a very rare case of middle lobe lung carcinoma occurring together with a hy.. Read More
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Vitreous Humor: A Short Review on Post-mortem Applications
Vitreous humor has been investigated since the 1960s, with many debates occurring over the years with regard to the usefulness of its specific applications. The composition of several electrolytes in post-mortem vitreous humour has been extensively studied. Using the fluid for determining the cause of death has also become commo.. Read More
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The determination of osteocyte viability is essential in bone research and clinical practice; however its determination at the time of sampling, without disruption of the bone matrix is difficult. The current clinical histological diagnosis of osteonecrosis requires the identification of empty osteocyte lacunae, which may take u.. Read More
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Extraovarian yolk sac tumor (YST) is an extremely rare malignancy occurring mainly in girls and young women of childbearing ages and commonly treated with fertility-sparing surgery and postoperative adjuvant chemotherapy. We report a case treated with neoadjuvant chemotherapy (NACT) followed by cytoredutive surgery and adjuvant .. Read More
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Primary Oral Melanoma: A Case Report with Immunohistochemical Findings
Melanoma is a potentially aggressive and rare malign neoplasm of melanocytic origin. Only 1% occurs in oral mucosa, accounting for 0.5% of all oral malignancies being more aggressive when compared with the cutaneous counterpart. The tumor occurs more frequently in the hard palate and gingiva. Despite the advances in biological k.. Read More
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A Retrospective Study of the Incidence of GIST in Scotland from 1995 to 1999
Background and aims: Gastrointestinal Stromal Tumours (GIST) are mesenchymal soft tissue neoplasms which express the c-kit receptor and are exquisitely sensitivity to tyrosine kinase receptor inhibitors such as imatinib. This has significantly improved prognosis so it is important to identify retrospective cases. Methods: Patien.. Read More
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Intussusception due to Inflammatory Fibroid Polyp Located at Ileum
Majority of adult intussusceptions have a well-defined pathological abnormality as the definite cause. We report a case of 27 year old woman presented with vomiting and abdominal pain. We received a polypoidal; dumbbell shaped mass measuring 4×3.5×1 cm arising from the mucosal surface at one end of the small bowel. O.. Read More
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Introduction: Renal Oncocytoma (RO) and Chromophobe Renal Cell Carcinoma (ChCCR) are within spectrum of “eosinophilic renal neoplasms” that can share morphological features. In some instances, it can be challenging differentiate both entities based only on the HE. For this reason, complementary ancillary techniques a.. Read More
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An Unusual Cause of Central Diabetes Insipidus in a Young Female
Central Diabetes Insipidus (CDI) in adults is most commonly occurs as a result of hypothalamo- pituitary surgery, head injury or various inflammatory and infiltrative disorders. CDI with mass lesions in the sellar-suprasellar area occurs due to infiltrative disorders like lymphoma, Langerhan’s cell histiocytosis, and infla.. Read More
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