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Airway Mucus Plugs in Community-Living Adults: A Study Protocol
Introduction: Mucus pathology plays a critical role in airway diseases like Chronic Bronchitis (CB) and Chronic Obstructive Pulmonary Disease (COPD). Up to 32% of community-living persons report clinical manifestations of mucus pathology (e.g., cough and sputum production). However, airway mucus pathology has not been systematic.. Read More
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Appropriate radiographic interpretation is critical for providing high-quality patient care. The radiograph’s wealth of data assists dentists in prescribing the best treatment option for their patients. Dental radiographs, particularly Ortho Pantomograms (OPGs) and periapical radiographs taken with low radiation doses, are.. Read More
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Introduction: This study aimed to assess the effects of cancer treatment on sarcoma types and to predict overall survival probabilities using nomograms. Methods: This study uses the SEER-18 database, version 2020, sponsored by the National Cancer Institute (NCI). The study cohort included participants diagnosed between 2000 and.. Read More
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ATP4a Expression during Pesticide Induced Lung Damage
Lung is vtial organ that contains more than 40 different cell types localised regionally and spatially with varied number of mitochondria. It is evident that every cell depends on the mitochondrial oxidative phosphorylation for the production and supply of ATP. Among the cells, one type of cell is bronchial epithelial cells that.. Read More
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Anaplastic Diffuse Large B-Cell Lymphoma (A-DLBCL) is a mysterious and rare disease; its histopathological features have not been fully clarified today. This paper provides a case in the left axillary lymph node; there are a large number of pleomorphic centroblast like cells with anaplastic characteristics and HRS like cells in .. Read More
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Locked posterior shoulder dislocations are uncommon and pose many difficulties in diagnosis. They are often overlooked during initial examination and delayed diagnosis adversely affects healing process. Apart from many open treatment options there are reports of single attempts to treat such cases arthroscopically. We present an.. Read More
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Cerebral malaria-associated over expression of pro-inflammatory cytokines and chemokines ultimately results in the up-regulation of adhesion molecules in the brain endothelium leading to sequestration of mature parasitized RBCs in the brain. The high-parasitic load subsequently results in increased mortality or development of ne.. Read More
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Background: This study was conducted in the blood centre at MMDU, Mullana. The aim of study was to calculate the discard rate during the study period and finding out the reasons responsible for them in order to provide suggestions for further improvisation in blood transfusion techniques. Design: Study was carried out over a pe.. Read More
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Human Tail in a New Born: A Case Report
Background: Human tails are rare congenital anomalies protruding from midline of the lumbosacral region covered by skin. Human tails are classified as true tail and pseudo tail. True tails, also known as vestigial tails are caudal, midline protrusion capable of spontaneous or reflex motion, consisting of skin covering with a com.. Read More
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DOCK2: A Potential Target for Obesity Associated Lung Injury
Obesity is pandemic worldwide and closely associated with many chronic diseases including cardiovascular diseases, diabetes, cancer, and several respiratory diseases. While increasing evidence suggests that obesity is related to lung inflammatory changes, the pathophysiology underling obesity associated lung injury remains poorl.. Read More
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Fuzuloparib was approved in China in 2020 for treating ovarian and other solid cancers in patients with germline BRCA (breast cancer gene) receiving second-line or above chemotherapy. It is a Poly Adenosine diphosphate-Ribose Polymerase (PARP) inhibitor developed by Jiangsu Hengrui Medicine Co., Ltd. PARP inhibits DNA repair in .. Read More
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Leg Ulcers: Associated with Sickle Eye Disease
Leg ulcers are a common sign in Sickle Cell Disease. But to what extent are they indicative of Sickle cell eye disease in these patients? This short communication, examines to determine to what extent leg ulcers predict the presence of sickle eye disease. This was a clinic based, comparative non-interventional study, conducted .. Read More
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Pathologist-Guided Approach to Deep Learning Prediction of Pediatric Posterior Fossa Tumor Histology
Background: CNS tumors remain among the most frequently discordant pathologic diagnoses in the field of pediatrics. In this study, we examined neuropathologist-guided deep learning strategies towards automation of tumor histology diagnosis targeting the three most common pediatric Posterior Fossa (PF) tumors. Methods: A retrosp.. Read More
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Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Diagnostic and Therapeutic Challenge
A 59-year-old woman was referred to our Advanced Lung Disease Center for consideration for lung transplantation for stage IV sarcoidosis. She initially presented three years earlier with worsening dyspnea. Highresolution computed tomography of the chest at that time demonstrated ground-glass opacities, traction bronchiectasis, a.. Read More
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Burden Disease to Systemic Lupus Erythematosus in Colombia, 2010-2020
Background: Systemic Lupus Erythematous (SLE) is a risky and high-cost disease in Colombia which is why the population is evaluated from 2010 to 2020, in addition to estimating the years adjusted by disability (DALY) due to systemic SLE in Colombia in the last decade, as well as describe the prevalence and sociodemographic facto.. Read More
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Objective: To compare the mean level of hemoglobin A1C between β-thalassemia traits and normal non-diabetic individuals. Study design: Case-control study. Place and duration of the study: Department of pathology, PAEC general hospital H/11-4 Islamabad for a duration of 6 months from January 2021 to June 2021. Methodology.. Read More
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Placental Vascular Bed Pathology: An Emerging Cause of Future Cardiovascular Events
Evidence is accumulating that hypertensive disorders of pregnancy and, specifically, preeclampsia produce longterm effects on the pregnant woman, as well as lasting consequences for the fetus. At the root of these consequences is the phenomenon coined defective deep placentation, characterized by profound placental vascular les.. Read More
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Background: Fusions between the EWSR1 gene and CREB family transcription factors have been reported in a variety of rare tumor types, including the head and neck tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma (CCC) of the salivary gland. Objective: To review the current literature on tumors where EWSR1-.. Read More
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Triple Negative Breast Cancer in Southeast Nigeria: A Review of 149 Cases; What is New?
Purpose: To determine the prevalence of Triple Negative Breast Cancer (TNBC) and its features. Second highlight what is new and applicable in our setting. Material and methods: Data of all immunohistochemical typed blocks for breast cancer was pulled and only those negative for Estrogen Receptor (ER), Progesterone Receptor (PgR.. Read More
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PTLDs are disorders with a spectrum ranging from “early” polyclonal proliferations resembling nonspecific plasma cell hyperplasia or infectious mononucleosis to clonal proliferations of B or T/NK cells. The incidence of PTLD after HSCT is approximately 0.8%-4.0%. The clinical manifestations of PTLD are variable relat.. Read More
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