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Erythropoietin Ameliorates Experimental Autoimmune Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder characterized by weakness and fatigability of skeletal muscles. Erythropoietin (EPO) is a cytokine required to maintain erythroid cells. Recombinant human EPO (rHuEPO) was found to act also on immune cells. Beneficial effects of rHuEPO therapy have been demonstrated in several ex.. Read More
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Neuroimmune Regulation in Health: Acute Febrile Illness and Healing
Adaptive Immunity (ADIM) is maintained by Growth hormone (GH), Prolactin (PRL), and during fetal life Placental lactones (PL) fulfill this role. Vasopressin (VP) is also an ADIM regulator. ADIM is also regulated by antigens and by cytokines and chemokines. Innate immunity (INIM) is the second part of our Immune System. This syst.. Read More
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The primary pathological mechanism for paraneoplastic neurological syndromes is believed to be a form of onconeural immunity where the cancer causes a cross-immune reaction with the neurons. In a previous study, using a proteomic approach, we detected an anti-brain-type creatine kinase antibody that was associated with paraneopl.. Read More
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International Consensus: Paraneoplastic Neurological Antibodies - are we there yet?
A survey amongst the participants of the Paraneoplastic Neurological Antibody Scheme, registered with United Kingdom National External Quality Assessment Service (UK NEQAS), across the UK, continental Europe and non- European countries examined various factors involved in the laboratory diagnostic methodologies, timely provision.. Read More
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VIP and PACAP as Regulators of Immunity: New Perspectives from A Receptor Point of View
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) are two neuropeptides acting through three common G-protein coupled receptors (VPAC1, VPAC2 and PAC1). Among their pleiotropic actions within the organism, VIP and PACAP are known to exhibit immunomodulatory properties in both the .. Read More
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Center Role of the Oxytocin-Secreting System in Neuroendocrine-Immune Network Revisited
The hypothalamic neuroendocrine system has extensive and bidirectional interactions with immune system. In parallel with the hypothalamic-pituitary-adrenal axis, the oxytocin-secreting system composed of hypothalamic oxytocin neurons and their associated neural tissues has also emerged as a major part of the neuroendocrine cente.. Read More
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Malignant and benign types of tumor, infiltrated in human brain are diagnosed with the help of an MRI scanner. Using the slice images obtained using an MRI scanner; certain image processing techniques are implemented to have a clear anatomy of brain tissues. One such image processing technique is hybrid Self Organizing Map (SOM).. Read More
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