Make the best use of Researched information from 700+ peer reviewed, Open Access Journals operated by 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business
Cytokines are key modulators of inflammatory responses, and play an important part in the defense and form mechanisms following trauma. After traumatic injury, an immuno- seditious response is initiated incontinently, and cytokines fleetly appear and serve as a controller of immunity. In pathologic conditions, imbalanced cytokin.. Read More
To read the full article Visit Full Article | Download Full Article
The ICD that Cause the Capable of Triggering Cytokine Release from Immune Cells
Despite advances in treatments like chemotherapy and radiotherapy, metastatic cancer remains a leading cause of death for cancer cases. While numerous chemotherapeutic agents can efficiently exclude cancer cells, long- term protection against cancer isn’t achieved and numerous cases experience cancer rush. Mobilizing and s.. Read More
To read the full article Visit Full Article | Download Full Article
Erosion of endothelial surface, disruption of endothelial glycocalyx and hyperinduction of inflammasome complexes are some of the main events taking place in early stages of COVID. Shedding of endothelial glycocalyx is also an important pathophysiologic finding in burn injury. It has also been shown that NLRP3 inflammosome is pi.. Read More
To read the full article Visit Full Article | Download Full Article
Background: The level of Mono Sodium Urate (MSU) in the human should be ideally kept below 6.o mg/dl. Above 6.8-7.2 mg/dl, crystallization may occur in tissues; resulting in the inflammatory response understood as acute gout attack. Alfred Baring Garrod and Alexander Ure felt that these concretions in the synovial tissues and ki.. Read More
To read the full article Visit Full Article | Download Full Article
COVID-19, the pandemic arising from the third coronavirus outbreak in the past 20 years, will not be the last. Identifying therapies for COVID-19, and possibly future outbreaks, is of great importance. COVID-19 is characterized by an initial phase of viral replication followed by an excessive pro-inflammatory response (cytokine .. Read More
To read the full article Visit Full Article | Download Full Article
MLPC are human cord blood-derived non-hematopoietic stem cells with extensive proliferative and differentiation capacity. TERT transfection of MLPC rendered them functionally immortal. Methods to create immortalized fully mature cells by differentiation or by direct fusion of TERT-MLPC to primary cells are described. Hepatocyte-.. Read More
To read the full article Visit Full Article | Download Full Article
Cytokine Levels in Plasma and PHA Activated T Cells in Head and Neck Cancer Patients
Cytokines play a pivotal role in cancer, as these act as mediators in response to several physiological factors, caused by disease burden or interventions like surgery, chemotherapy and radiation. The levels of these cytokines can also act as biomarkers, and help in predicting a relapse episode or by analysing the efficacy of an.. Read More
To read the full article Visit Full Article | Download Full Article
Achilles Tendons from T-Lymphocyte Deficient Mice Exhibit Improved Healing.
Purpose/Aim of Study: Tendon healing involves a complex, coordinated series of events that, despite new therapies to improve healing, results in scar. The “nude” T-lymphocyte deficient model is a genetic strain exhibiting a loss of function in the Foxn1 gene. Nude mice cannot generate mature T-lymphocytes, are unable.. Read More
To read the full article Visit Full Article | Download Full Article
GMEssential Role of GM-CSF-Dependent Macrophages in Human Autoimmune and Inflammatory Responses
Macrophages are important cells in the innate immune system that express toll-like receptors, produce various cytokines, and have a major role in both inflammation and autoimmune diseases. These cells undergo differentiation into GM-CSF-dependent or M-CSF-dependent macrophages in response to influences in the microenvironment. B.. Read More
To read the full article Visit Full Article | Download Full Article
A Multi Gene Targeting Approach to Treating Liver Diseases with Metadichol®
Liver diseases are becoming a major health concern. In the developing countries it is due to microbial infection. In the rest of the developed world it is due to alcohol abuse. Chronic liver disease and cirrhosis are a significant health concern in western countries. It is the fifth most common cause of death, after heart diseas.. Read More
To read the full article Visit Full Article | Download Full Article
Cytokine Profile of Mesenchymal Stem Cells for their Wound Healing Properties
Wound healing properties of Mesenchymal Stem Cells (MSC) is a topic of great interest and their mechanism of action is mainly attributed to their paracrine effects and their potential to differentiate in the area of contact, thereby resulting in wound healing. Umbilical Cord (UCMSC) derived MSC and Bone marrow derived MSC (BM MS.. Read More
To read the full article Visit Full Article | Download Full Article
Objectives: CRISPR/Cas9 is currently the primary tool used for genome editing in mammalian cells. To cleave and alter genomic DNA, both the Cas9 nuclease and a guide RNA (gRNA) must be present in the nucleus. One preferred method of introducing these reagents is direct transfection of a recombinant Cas9 protein complexed with a .. Read More
To read the full article Visit Full Article | Download Full Article
Objective: We have previously shown changes in protein, immune cell, nitric oxide a neurotrophic factor content and distribution in the olfactory bulb of an endotoxin-treated rat model, as all these factors have been shown to be involved in neurodegeneration. We expanded our studies by fluorescently imaging smooth muscle actin a.. Read More
To read the full article Visit Full Article | Download Full Article
Neutrophil CD64 Expression in CrohnâÃâ¬Ãâ¢s Disease following Anti-TNF-Îñ Therapy
Objective: Anti-TNF-α therapy is an effective therapy for Crohn’s disease (CD). Thus anti-TNF-α therapy may alter CD64 expression, one of the Fc receptors for IgG, in CD. We investigated CD64 expression on neutrophils before and after treatment with anti-TNF-α therapy in CD. Methods: A total of 11 patien.. Read More
To read the full article Visit Full Article | Download Full Article
The first objective of this study was to identify if soluble tumor necrosis factor-receptor 1 (sTNFr1) and -receptor 2 (sTNFr2) are modulated by vitamin D status (insufficient vs. sufficient). The second objective was to reveal if soluble TNF receptors fluctuate with serum 25-hydroxyvitamin D (25(OH)D) concentrations following a.. Read More
To read the full article Visit Full Article | Download Full Article
Triptolide, a Chinese plant medicine from Tripterygium wilfordii Hook F, has been shown to have inhibitory effects on macrophage activities, and we recently found that it induces sudden macrophage cell death in the presence of bacterial lipopolysaccharide (LPS). In this present study, we examined precise mechanisms underlying in.. Read More
To read the full article Visit Full Article | Download Full Article
The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift in the understanding of allergic airway disease pathogenesis. Prior to the discovery of ILC2s, Th2 cells were largely thought to be the primary source of type 2 cytokines; however, activated ILC2s have since been shown to contribute signifi.. Read More
To read the full article Visit Full Article | Download Full Article
Unexpected Macrophage Activity Alters the Inflammatory Process in Necrotizing Enterocolitis
Objective: Macrophages play a role in clearing bacteria from the gut in the initial stages of necrotizing enterocolitis (NEC). Macrophage Inflammatory Protein-1α (MIP-1α), also known as CCL3, is a chemokine produced by macrophages that enhances the immune response. It acts as both a recruiter of immune cells and a co.. Read More
To read the full article Visit Full Article | Download Full Article
Impacts of Interleukin-17 Neutralization on the Inflammatory Response in a Healing Ligament
In this study, we sought to improve ligament healing by modulating the inflammatory response after acute injury through the neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease inflammatory cell infiltration and cytokine production. Administration of an Interleukin-17 neutralizing antibody (IL-17 NA) im.. Read More
To read the full article Visit Full Article | Download Full Article
Mesenchymal Stem Cell Therapy on Tendon/Ligament Healing
A normal healing response after ligament and tendon rupture results in scar formation and an inferior tissue that fails to emulate its original structure, composition, and function. More regenerative healing (closer to the original) can be obtained through early suppression of inflammatory cells and associated cytokines. Examina.. Read More
To read the full article Visit Full Article | Download Full Article