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Novel Cytokine Pathways in Autoimmune Disorders: Insights and Therapeutic Targets
Autoimmune disorders, characterized by the immune system’s aberrant attack on self-tissues, have traditionally been treated with broad-spectrum immunosuppressants. Recent research into cytokine pathways has unveiled novel targets for more specific and effective therapies. This review explores emerging cytokine pathways inv.. Read More
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Cytokine Profiles in Viral Infections: Implications for Disease Severity and Treatment
Cytokines are pivotal in orchestrating the immune response to viral infections, influencing disease severity and therapeutic outcomes. This article examines the role of cytokine profiles in various viral infections, focusing on how early and chronic infections alter cytokine production and impact disease progression. We discuss .. Read More
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Interleukin-6 as a Biomarker for Chronic Inflammatory Diseases: A Comprehensive Review
Interleukin-6 (IL-6) is a multifunctional cytokine involved in immune regulation, inflammation, and hematopoiesis. Elevated levels of IL-6 are associated with various chronic inflammatory diseases, including rheumatoid arthritis, Crohn’s disease, psoriasis, and cardiovascular diseases. This comprehensive review explores th.. Read More
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Targeting Cytokine Storms in COVID-19: Current Strategies and Future Directions
The COVID-19 pandemic has highlighted the critical role of cytokine storms in disease severity, prompting intensive research into therapeutic strategies aimed at mitigating these hyperinflammatory responses. This review explores current approaches and future directions in targeting cytokine storms in COVID-19, emphasizing immuno.. Read More
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Role of Cytokines in Cancer Immunotherapy: Recent Advances and Clinical Applications
Cancer immunotherapy has emerged as a revolutionary approach in cancer treatment by leveraging the immune system’s inherent capability to target and eliminate cancer cells. Among the key players in this field, cytokines play a crucial role in orchestrating immune responses against tumors. This review explores the recent ad.. Read More
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Cytokine-Mediated Regulation of Metabolic Disorders: Mechanisms and Therapeutic Opportunities
Metabolic disorders, encompassing obesity, Type-2 diabetes, and metabolic syndrome, pose significant global health challenges. Cytokines, key signaling molecules primarily associated with immune response regulation, also play crucial roles in the pathophysiology of these disorders. This review explores the mechanisms through whi.. Read More
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Exploring the Interplay between Microbiome and Cytokine Signaling in Gut Health
The gut microbiome and cytokine signaling interact synergistically to maintain immune homeostasis and influence overall gut health. This review explores the dynamic interplay between gut microbiota and cytokine production, highlighting how microbial communities shape immune responses and vice versa. Understanding these int.. Read More
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Neuroinflammation, driven by cytokine dysregulation in the central nervous system (CNS), contributes significantly to the pathogenesis of various neurological disorders including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. Cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alp.. Read More
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Advances in Cytokine Research: From Bench to Bedside Applications in Rheumatoid Arthritis
This article reviews recent advances in cytokine research and their applications in the management of rheumatoid arthritis (RA). Cytokines play a critical role in RA pathogenesis by mediating inflammation and joint destruction. Key cytokines such as TNF-alpha, IL-6, IL-1, and IL-17 have been targeted with biologics and small mol.. Read More
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Cytokine-Induced Gene Expression and Epigenetic Modifications: Implications for Disease and Therapy
Cytokines are critical mediators of the immune response, influencing cellular processes through the regulation of gene expression and epigenetic modifications. This article explores the mechanisms by which cytokines induce changes in gene expression via pathways such as JAK-STAT and MAPK, and how these changes contribute to dise.. Read More
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Emerging Cytokine-Based Therapies: Challenges and Future Directions
Cytokines, the signaling molecules of the immune system, play crucial roles in orchestrating immune responses and maintaining tissue homeostasis. Their dysregulation is implicated in various diseases, leading researchers to explore cytokine-based therapies as promising avenues for treatment. This article examines the current lan.. Read More
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Role of Tumor Necrosis Factor in Autoimmune and Inflammatory Diseases: From Bench to Bedside
Tumor Necrosis Factor (TNF) is a pivotal cytokine involved in regulating immune responses and inflammatory processes, playing a critical role in the pathogenesis of various autoimmune and inflammatory diseases. This article explores the multifaceted functions of TNF, from its molecular mechanisms in immune regulation to its clin.. Read More
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The Impact of Cytokines on Metabolic Disorders: Insights into Obesity and Diabetes
Metabolic disorders such as obesity and diabetes mellitus represent significant global health challenges characterized by dysregulated energy metabolism and chronic inflammation. Cytokines, key regulators of immune responses and inflammation, have emerged as critical mediators in the pathogenesis and progression of these disorde.. Read More
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Cross-talk Between Cytokines and Chemokines in Immune Cell Migration and Activation
The interplay between cytokines and chemokines is pivotal in orchestrating immune responses by regulating immune cell migration, activation, and effector functions. Cytokines, including interleukins, interferons, and tumor necrosis factors, modulate immune cell behavior through specific receptor interactions, influencing gene ex.. Read More
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Cytokines in Neuroinflammation: Pathways and Potential Therapies
Neuroinflammation, characterized by immune activation within the central nervous system (CNS), is a pivotal component of various neurological disorders. Cytokines, key mediators of immune responses, play critical roles in modulating neuroinflammatory processes. These small proteins orchestrate complex signaling cascades that inv.. Read More
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Cytokine Storms: Understanding the Mechanisms and Implications in Viral Infections
Cytokine storms represent a critical immunopathological phenomenon observed in severe viral infections, characterized by an excessive release of pro-inflammatory cytokines. This dysregulated immune response can lead to widespread tissue damage, organ dysfunction, and poor clinical outcomes. Understanding the underlying mechanism.. Read More
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Advances in Cytokine Research: Implications for Treatment of Chronic Inflammatory Diseases
Recent advances in cytokine research have revolutionized the understanding and treatment of chronic inflammatory diseases. Cytokines, key regulators of immune responses, play a pivotal role in the pathogenesis of conditions such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Targeted biologic therapies that .. Read More
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The Role of Interleukins in Cancer Progression and Immunotherapy
Abstract Interleukins (ILs) play a pivotal role in cancer biology by modulating immune responses and shaping the tumor microenvironment. While certain ILs promote tumor progression through mechanisms such as proliferation and angiogenesis, others enhance anti-tumor immunity and serve as targets for immunotherapy. This review exa.. Read More
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Cytokine Signaling Pathways in Inflammatory Response: Mechanisms and Modulation
Cytokines play pivotal roles in orchestrating inflammatory responses by mediating communication between immune cells and regulating gene expression. This review explores the diverse signaling pathways of cytokines— such as Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kappa B (NF-.. Read More
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Regulatory Roles of Cytokines in Autoimmune Diseases: New Therapeutic Targets
Autoimmune diseases arise from the immune system mistakenly attacking the body’s own tissues, leading to chronic inflammation and tissue damage. Central to these diseases are cytokines, small proteins that regulate immune responses and play pivotal roles in the development and progression of autoimmune conditions. This rev.. Read More
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