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A Short Interfering RNA (siRNA) Molecular Beacon for the Detection of Mycobacterial Infection
In latent TB, the ability of Mycobacterium tuberculosis to invade and survive within macrophages of the pulmonary granuloma is attributed to protein products of mammalian cell entry (mce4) operon genes (A-F). These are cholesterol transporters which facilitate the transport of host lipids into the mycobacterium allowing long ter.. Read More
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Cloning of resistance gene analogues against diverse pathogens from variety of plants in last decade has revealed that many of them share high level of conserved sequence motifs. The conserved backbone of amino acid motifs present in Nucleotide Binding Site (NBS) domain makes it possible to isolate resistance gene analogues by P.. Read More
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The Tripeptide, GHK, Induces Programmed Cell Death in SH-SY5Y Neuroblastoma Cells
GHK-Cu is a tripeptide that is found in plasma and increases fibroblast proliferation and is widely used in wound healing creams. Studies show that GHK-Cu stimulates the level of p63, a member of the antitumor suppressor family which includes p53 and p73. Because of its effect on p63, we tested the hypothesis that GHK induces ap.. Read More
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Viability of Coffee Leaf Rust (Hemileia vastatrix) Urediniospores Stored at Different Temperatures
Viability of spores samples of Hemileia vastatrixf, the fungal pathogen causing leaf rust disease in coffee was checked after storing at room temperature, -20°C and -80°C for one year. While the spore samples lost their viability as early as 45 days at room temperature and thus retained viability for about 120 days at -2.. Read More
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Dopamine does not penetrate the blood-brain barrier and IPX 750, a dopamine glycoconjugate, is designed to improve dopamine transport across the blood brain barrier. IPX-750 binds to D1/D5 receptors in vitro and eliminates Parkinson’s disease symptoms in three animal models. These studies were conducted to confirm the bioa.. Read More
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Neurodegenerative disorders have been linked to an array of external factors ranging from atmospheric pollutants to diet related additives. In our study we have investigated BMAA a neurotoxin produced by cyanobacteria, which gets an easy entry into human food chain via sea food and water, Aluminium which is believed to be presen.. Read More
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Physical hydrogels based on poly (vinyl alcohol) (PVA) were synthesized in the presence of natural polysaccharides, either hyaluronan or Chondroitin sulphate, in order to obtain versatile biomaterials with enhanced performances. The physical network is obtained by the freeze thawing technique, a simple method widely used for str.. Read More
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An Artificial Silk-elastin-like Protein Suppresses Cells Adhesion without Apoptosis
The objective of this study is to evaluate the effect of an artificial silk-elastin-like protein (SELP) on the adhesion and apoptotic behavior of cells. When MC3T3-E1 cells were cultured on dishes coated with different concentrations of SELP, the cells adhesion was suppressed with the increasing coating concentration. As control.. Read More
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Haematological Studies on Broiler Chickens Fed with Different Levels of Artemia Urmiana
The present study was carried out on broilers to study the effect of Artemia Urmiana on hematological parameters for a period of 56 days (8 weeks). In this study 190 one-day old broiler chicks from Ross 308 strain were divided into five equal groups: L1, L2, L3, L4 (Test groups) and control group. The control diet contained 5% f.. Read More
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Magnetic microspheres have many bio-medical applications, but they have contact with the blood before reaching to their target place in many cases, so the study of the effect of these microspheres on the blood can lead to optimization of the use of these microspheres. Five groups of normal blood samples were incubated with 10 mg.. Read More
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A total of 240 alkaliphilic bacteria were isolated from samples collected from alkaline soda lakes of Ethiopia and were screened for the production of alkaline proteases. Of these, 30% were protease positive indicating the abundance of protease producing microorganisms in these habitats. The Bacillus sp. designated as C45 that g.. Read More
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Ropivacaine versus Bupivacaine in Postoperative Pain Control
Objective: The aim of this study was to compare between 2 types of long acting anesthetics: bupivacaine 0.5% and ropivacaine 0.75%, in terms of their duration of anesthesia, duration of analgesia and their effect in controlling postoperative pain after surgical removal of impacted lower third molars. Material and Methods: This s.. Read More
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A wide range of biocompatible and biofunctional implant devices from dental screw posts to porous hip stems designed for stress compatibility, cementless fixation by bone cell ingrowth, and long-term infection defense employing antibacterial, nanoparticulate silver are illustrated in this review of contemporary .. Read More
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Serratia marcescens DSM 30121T was tested for their chitinolytic activity on colloidal chitin agar. The production of the chitinase by Serratia marcescens DSM 30121Twas optimized by using of different parameters such as temperature, pH-value, colloidal chitin concentration and incubation time. The obtained .. Read More
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Mycobacterium smegmatis mc2 155 contains a Ribonucleotide reductases (RNR), which catalyses the irreversible reduction of ribonucleotides to the corresponding 2 ÃŒÂdeoxyribonucleotides required for DNA replication and cell proliferation. The aim of this work was the development of a rapid assay for .. Read More
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1,3-Propanediol Production by Clostridium Butyricum in Various Fed- Batch Feeding Strategies
The aim of this study is to propose different fed-batch strategies during the fermentation of glycerol into 1,3-Propanediol, which show the influence of the initial concentration in glycerol and the feed flow on the behaviour of Clostridium butyricum . The kinetic study of the conversion of glycerol .. Read More
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In this paper the key odorants effects of parsley ( Petroselinum crispum Hoffm) and fennel ( Foeniculum vulgare ) in the growth of Lactobacillus casei subsp rhamnosus , were studied. Parsley and fennel essential oils were obtained by hydrodistillation with 0.14% yield from parsley and 1% from fennel. All experiments were car.. Read More
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Study of the use of date’s syrup like substrate a fermentation substrate for Acid lactic production gave as interesting results, the micro-organism implemented is kind Lactobacillus delbrueckii subsp. bulgaricus , cultivated in bathe fermentation. Three culture mediums were tested, the date syrup, date .. Read More
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A novel device was designed to perform electrophoretic deposition under tightly controlled conditions. The device physical parameters were investigated by depositing three different viscosity grades of sodium alginate hydrogels. A thin metallic rectangular substrate was used to obtain the various time dependant deposition rates .. Read More
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In Vitro Study of Photocurable Embolization Agent for Cerebral Aneurysms
The use of liquid embolic agents for the endovascular treatment of cerebral aneurysms has been reported in the neurosurgical literature. A major limitation of these agents is their relatively poor control of hardening ability. In this study, the technical feasibility of a novel gelatin-based photocurable liquid agen.. Read More
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