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Recently structural analogue-based drug discovery has become an important tool for designing more potent drugs. This study uses SAR, pharmacophore study and structural analogue-based novel drugs to design selective inhibitor molecules using internet-based tools. Substituted acyl hydrazones are known for wide variety of biologica.. Read More
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Fluoroquinolones are among the most promising antibiotic drugs for Tuberculosis treatment. Although high levels of fluoroquinolone resistance have been detected among many common bacterial pathogens, little is known about the fluoroquinolone resistance of M. tuberculosis especially at the baseline. The present study was thus aim.. Read More
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Surface Immobilization of Antibacterial Quorum Sensing Inhibitors by Photochemical Activation
Infection of implanted medical devices is one of the major causes of nosocomial infections. A significant proportion of the devices become colonized by bacterial biofilms, thus resulting in high morbidity and risk of mortality. This study focuses on the non-specific covalent attachment of potent quorum sensing (QS) and biofilm i.. Read More
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Tissue Cultured Versus Traditionally Grown Pineapples: Growth and Nutrient Profile
Background: Ananas comosus, commonly known as pineapple, is a fruit that is endorsed by the Ministry of Agriculture to be economically important to the island. Tissue culture maybe used as an additional method of propagation to supplement traditional methods to increase productivity. This study was therefore designed to assess t.. Read More
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Bacterial Modes of Action for Enhancing of Plant Growth
The greatest issue affecting the sustainability of broad acre cropping both environmentally and economically is the requirement of fertilizers. These are based on mined phosphorous or other mineral ores, ammonia produced through the Harbour-Bosch process and industrially manufactured potash. As global demand for fertilizers .. Read More
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Some Physiological Insights of 2,4-D Sensitivity in an Aquatic Fern: Azolla pinnata R.Br
In an experiment with Azolla pinnata R.Br. under varying concentrations of herbicide (2,4-D), it reveals that the fern species has an wider ranges of physiological activities in moderation. Initially, the effects of the herbicide were reflected with minimum changes in dry matter accumulation in a dose dependent manner. The c.. Read More
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Acid-soluble collagen (ASC) from the fish skin of African catfish (Clarias gariepinus), Salmon (Salmo salar) and Baltic cod (Gadus morhua) was extracted and characterized. The ASC extraction yield was 75%, 73% and 68%, respectively. The denaturation and melting temperatures of African catfish ASC (29.3°C and 100.0°C) wer.. Read More
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Introduction: A synthetic polymer polyethylene glycol (PEG), was conjugated to fibrinogen as a threedimensional and biodegradable skin wound dressing matrix. This PEG-fibrinogen (PEG-fib) was tested in vivo in a skin wound time course study for its biocompatibility and biodegradation, after being delivered into the wound by inje.. Read More
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Cell-derived extracellular vesicles (EVs) are heterogeneous population of phospholipid-based endogenously produced particles. EVs are detected in several biological fluids and tissues as biomarkers of diseases and target of medicines. The conventional approach for measuring the MPs is based on commonly used flow cytometry, fluor.. Read More
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Biomatrices in Urethral Reconstruction
Urethral reconstruction is still a big challenge in urology. Traditionally, the penile skin or buccal mucosa was used as graft for replacement. However, the morbidity of the donor site was reported previously. Furthermore, there is a lack of an adequate autologous donor graft in many cases. The tissue engineered urethra may prov.. Read More
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Implantable Magnetic-Dielectric Composites for Prolonged Hyperthermia Treatment of Hepatic Lesions
The inefficiency and the low success rates of surgical resection and side effects of chemotherapy used in the treatment of hepatocellular carcinoma have elicited substantial research interest in alternative methods for treatment. Here we report the use of magnetic-dielectric composite of Chromium doped Iron Oxide (Cr0.2Fe1.8O3) .. Read More
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Globalization of Clinical Trials: Ethics and Conduct
The underlying motif of the article “Ethical and Scientific Implications of the Globalization of Clinical Research” is that the clinical trials conducted in developing countries are justified; and that the suggested changes for improvement in the ethical standards can safeguard the interests of people in those areas... Read More
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Extraction of Proteases from Medicinal Plants and their Potential as Anti- Viral Targets
Medicinal plants especially leaves are used in traditional medicine for rapid anti-viral therapy against infectious diseases. Protease, a potential candidate in medicinal plants is not so for studied in leaves. So an attempt was made to determine the protease activity of various medicinal plants especially leaves. Buffers of dif.. Read More
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Background: Bambusa balcooa Roxb. is a species with multipurpose utility and economic value. Natural forests are being depleted due to human activities so it is necessary to grow important bamboo species in plantations. Effective propagation methods are required to generate large quantities of material for planting and culm cutt.. Read More
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Evaluation of Bioethanol Production from Ulva lactuca By Saccharomyces cerevisiae
Ulva lactuca acts a vital potential marine energy crop. Reducing sugars from U. lactuca were obtained and evaluated for the bioethanol production by Saccharomyces cerevisiae. The optimization process was investigated by Plackett-Burman experimental design followed by immobilization technique on supported solid materials. Results.. Read More
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Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few clinical trials involving humans. Aim: This study reviewed all of the English la.. Read More
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Effect of Activating Lacto Peroxidase System (LPS) On Quality and Storage Stability of Soft Cheese
Utilization of intrinsic enzymatic activity to increase the quality and storage stability of food product is a novel biological and biochemical technique. The aim of present research was to minimize the microbial, physiochemical and protein degradation changes in soft cheese to enhance its quality and shelf life by activating la.. Read More
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Dillenia pentagyna belongs to family Dilleniaceae, is commonly known as Karkat. It is small deciduous tree reaching up to the height of 10-12 m with a straight bole. The species is distributed throughout in India including Andaman & Nicobar. It is highly important medicinal tree species. Its leaves, fruits and bark show anti.. Read More
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Structural analysis of deuterated proteins, which are essential for neutron protein crystallography, involves refinement of X-ray crystallographic data using atomic or molecular thermal stability factors. Analysis of high resolution (~0.9 Å) X-ray data can localize some of the hydrogen atoms in a protein molecule. Thermal .. Read More
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Advances in Cell Culture: More than a Century after Cultivating Cells
To elucidate and understand complex physiological mechanisms, in vivo research is the gold standard. However, in 1907, Harrison started the in vitro cell culture as we know today, opening a path for new assays and techniques. This was a major advance in the scientific field. The possibility to monitor cell growth, differentiatio.. Read More
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