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HPLC-UV Method for the Determination of Enalapril in Bulk, Pharmaceutical Formulations and Serum
A simple reversed phase HPLC method have been successfully developed and validated for the quantitative determination of enalapril maleate (ENP) in bulk material, pharmaceutical formulation and serum. Purospher Start C 18 (250 cm x 4.6 mm, 5 μm) and Hypersil, ODS columns were used. The mobile phase, methanol-acetonitrile-w.. Read More
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The over-expression of tumor necrosis factor alpha (TNF-alpha) has been associated with various diseases, particularly autoimmune diseases such as rheumatoid arthritis and Crohn’s disease. Some biologic therapies for these diseases specifically target this cytokine, sequestering it, and preventing its interaction with it.. Read More
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A simple, sensitive, rapid and economic high performance thin layer chromatographic method has been developed for determination of amlodipine besylate and olmesaratan medoxomil in human plasma by liquid liquid extraction using paracetamol as an internal standard. The plasma sample was extracted using mixture of methanol: acetoni.. Read More
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A highly sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for quantitation of arabinofuranosylguanosine 5’-triphosphate (ara-GTP) in human peripheral blood mononuclear cells (PBMC). The determination of ara-GTP in PBMC was validated using a standard addition method with the human Tly.. Read More
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Development and Validation of Analytical Methods for Pharmaceuticals
Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The official test methods that result from these processes are used by quality control laboratories to ensure the identity, purity, potency, and performance of drug products. This review gives inf.. Read More
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Stability Study of Fluconazole Applying Validated Bioassay and Stability-Indicating LC Methods
Chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, understanding the factors that change the stability of pharmaceuticals and identifying ways to guarantee their stability are important. In this work stability-indicating Liquid Chromatographic (LC) and bioassay methods wer.. Read More
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Pentafluorophenylpropyl (PFPP) stationary phases allow for dipole-dipole, pi-pi, charge transfer and ion- exchange interactions and have shown unique retention of small, polar analytes. PFPP columns are able to retain protonated bases in the presence of high percentages of an organic modifier, which is a suitable condition for l.. Read More
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The evolution of molecular technologies has had a major impact on many fields of research, including epidemiology. At the core of this branch of epidemiology is the need for high specificity typing of disease agents: to confirm trace back of disease to origin, to monitor the spread of disease causing strains, to study population.. Read More
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Zinc oxide (ZnO) nanostructures have attracted much interest for intracellular electrochemical measurements because of its large surface area, and its biocompatible properties. To design intracellular biosensors for metal ions and glucose, we grew ZnO nanorods on the tip of borosilicate glass capillaries (0.7µm in diameter.. Read More
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A highly senstive and rapid LC-MS/MS method has been developed and validated for the estimation of desvenlafaxine in rabbit plasma. The chromatographic separation was performed with 0.2% formic acid: methanol at flow rate of 0.4 mL/min on Symmetry Shield RP18 column with a total run time of 3.0 min. TheMS/MS ion transitions moni.. Read More
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A simple, selective, precise densitometric HPTLC method for analysis of 6-Gingerol both in chloroform extract of Zingiber officinalis and in laxiwin formulation has been developed and validated. The method employed HPTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The phytoconstituent, 6-Ginge.. Read More
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A rapid and sensitive RP-HPLC method with UV detection and UV spectrophotometric method for routine Pharmaceutical quality control of aceclofenac, paracetamol and tizanidine in tablets formulation was developed. Chromatography was performed by using Phenomenex-Luna C 18 (250 x 4.6 mm, 5μ) with a m.. Read More
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Proteomics– Current Novelties and Future Directions
Increasingly in the last decade, proteomics has become a widely used technique in the field of cell biology. This is due not only to improvements in technology and analytical procedures, but also because of the innovative and diverse ways in which the methodologies of protein and peptide analy.. Read More
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Proteome Analysis of B. subtilis in Response to Calcium
While the role of calcium binding proteins (CaBPs) in cell signaling pathways and homeostasis is well established in eukaryotic cells, the physiological function of CaBPs in prokaryotes is unknown. Although several CaBPs have been identified and sequences predicted in a variety of prokaryotic genomes, biochemical and functional .. Read More
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An Evidence Scoping Review of Photodynamic Therapy (PDT) in the Treatment of Cancers
In this invited paper, we applied standard methods of evidence synthesis and critical appraisal to summarize the current state of clinical evidence on PDT for the treatment of different types of cancers. A total of 266 studies spanning 11,427 patients and 34 different types of cancer were reviewed... Read More
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The surface of the airways that conduct gases into and out of the lungs has components that protect the host from inhaled and aspirated pathogens. The thin (4-7 mm height) layer of airway surface liquid (ASL) that lines the airways has physicochemical properties that are important for normal functi.. Read More
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Trace Assay for In-vivo Tissue Using a Fluorine-Doped Graphite Sensor
The renewable and low-cost biosensor consisting of graphite pencil counter, reference, and fluorine immobilized on a graphite pencil (FPE) working sensor was explored for use in cyclic voltammetry (CV) and square-wave stripping voltammetry (SW) in cobalt assay. In the voltammetric study, the analyt.. Read More
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Recently, there has been a heightened public awareness of drug safety across the globe. Nonclinical and clinical pharmacokinetic and toxicokinetic toxicology safety studies all require that the study samples be analyzed under the auspices of good laboratory practice (GLP) standards. GLPs are follow.. Read More
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Enhancement of Intact- Ion Yield and Surface Sensitivity by Argon-cluster SIMS
In secondary ion mass spectrometry (SIMS) of organic samples, damages induced by the primary ions are crucial. The mass of intact ions (secondary ions not dissociated) currently detectable is only as high as the 1,000 Da at best, which prevents the technique from being extended to apply to organic .. Read More
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A Review of Photodynamic Therapy for Intraocular Tumors
Photodynamic therapy (PDT) has been used in ophthalmology for various vascular conditions affecting the retina and choroid since the late 1990’s. As of 2000, verteporfin (Visudyne; CIBA Vision Corp, Duluth, Ga) photosensitizer for ocular conditions was used in treatme.. Read More
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