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FTIR: A Novel Bio-Analytical Technique
Fourier Transform Infra Red (FTIR) spectroscopy is a magnificent technique. Infrared spectroscopy is based on the fact that molecules absorb specific frequencies that are characteristic to the structure. These absorptions are resonant frequencies of the absorbed radiation that matches with the frequency of the bond or group that.. Read More
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Galanthamine hydrobromide (GAL HBr), approved material for treatment of mild to moderate Alzheimer’s disease, is a centrally-acting reversible acetylcholinesterase inhibitor (AChEI) that is currently under evaluation as a therapeutic countermeasure against organophosphorus G- and V-Series nerve agents, which can induce rap.. Read More
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Development and Validation of an HPLC Method for Quantifying Dapiprazole in Bulk Preparations
A simple, precise, rapid and accurate Reverse phase HPLC method was developed for the estimation of Dapiprazole in bulk form. A Thermo hypersil C-18 column (250 mm×4.6 mm 5μm) with mobile phase consisting of mixture of methanol: acetonitrile: and ortho-phosphoric acid in the ratio of 89: 9: 1 (v/v) at pH 5.8 adjusted wi.. Read More
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Thermostability Comparison of Two Solid States of Cefpiramide
Cefpiramide is susceptible to many factors, including high temperature. Two solid states were observed in cefpiramide: a crystalline form and an amorphous one, and both the accelerated (40°C ± 2°C /75% ± 5% relative humidity (RH)) and stress (60°C ± 2°C / 75% ± 5% RH) stability study d.. Read More
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Pharmacokinetic studies are essential towards determining bioequivalence and establishing pharmacokinetic profiles for drug moieties requires accurate quantification. We report a rapid, sensitive, and robust method for the determination of acyclovir in human plasma and its validation towards evaluating the bioequivalence of drug.. Read More
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Extraction of Diosgenin, a Bioactive Compound from Natural Source Dioscorea alata Var purpurae
Diosgenin, a commercially important bioactive sapogenin, extracted from tubers belonging to Dioscorea species, is used as a precursor in the manufacturing of sex hormones, oral contraceptives and other pharmaceutically important steroidal drugs. Diosgenin content of two Indian variety viz., D. deltoidea and D. prazeri ranges fro.. Read More
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With NMR Towards New Diagnostic Methods For Dengue
Dengue is a very common viral disease in tropical countries. From time to time it has become epidemic, hindering economics and affecting the social system. Early starting treatment reduces recovery time and suffering of the patients. But, the usual diagnostics is done by detection of the antibodies, which can only be done after .. Read More
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A simple Multicomponent Spectrophotometric method for simultaneous estimation of Metaxalone and Diclofenac Potassium in combined tablet dosage form had been proposed. Considering the absorption spectra of both analytes in the range of 220-350 nm in methanol, the four wavelengths of equal intervals of 40 nm were selected as 350 n.. Read More
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Composite: The Wonder Material
The term ‘composite’ has been used in material science refers to a material made up of a matrix containing reinforcing agents. The beginning of composite materials may have been the bricks, fashioned by the ancient Egyptians from mud and straw. Nearly 70 years ago, a number of technical products and other commodity m.. Read More
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Oxidative Absorption of Hydrogen Sulfide using Iron-chelate Based Process: Chelate Degradation
Oxidative absorption of hydrogen sulfide into a solution of ferric chelate is studied in stirred cell glass reactor. The experiments are performed to investigate degradation of chelates viz., NTA, EDTA and DTPA at 313 K temperature, pH 6, Iron concentration 10000 ppm and Fe-Chelate molar ratio 1:2. Oxidative absorption of hydrog.. Read More
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Labeling proteins with fluorescent dyes offers a powerful tool for monitoring protein interactions in vitro and in vivo. In order for this tool to be effective, the nature of the dyes - absorbance and emission properties, solution stability, pH range, and mechanisms for protein interaction - must first be considered. Two new asy.. Read More
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A simple and sensitive High-Performance Liquid Chromatography (HPLC) method with fluorescence detection for quantitation of telmisartan in rabbit plasma was developed and validated. Separation of telmisartan from plasma components was achieved on a Chromolith RP18e column (100 x 4.6 mm 5 μ). Losartan was used as an internal s.. Read More
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Ursolic and betulinic acids are very useful nutraceuticals available in herbs. Their quantitative estimation from the solvent extracts of the herbs is a great challenge. So far all the chromatographic methods available for identification and quantification of these acids are distinctly different, meaning thereby, each acid would.. Read More
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Characterization of Clostridium acetobutylicum Protein Interaction Network from Butanol Fermentation
Successful industrial production of butanol requires an in depth knowledge of Clostridium acetobutylicum. Development of computational approaches for protein interaction studies enabled us to generate a predicted protein interaction network of C. acetobutylicum ATCC 824. In this study, over 400 proteins from C. acetobutylicum we.. Read More
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Background: Patients on chronic opioid therapy are often closely monitored to identify prescribed or nonprescribed medications and/or illicit substances and to identify medication use that may lead to adverse events. Monitoring is typically performed using a combination of clinical tools and assessment methods that often include.. Read More
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Analytical Considerations When Monitoring Pain Medications by LC-MS/MS
Background: Laboratory urine drug testing of patients on chronic opioid therapy requires providing a large test menu of medications commonly prescribed for this population as well as metabolites and illicit substances. It has been shown that liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the preferred method to ana.. Read More
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Current Vision of Genomic Research and Its Positive Impact on GlobalCommunity
Genomics has its own application in wide range of life science research. Recent studies are now being concentrated on functional and comparative aspects of genomics and that makes an efficient platform for drug discovery and pharmaceutical research. In this note, we have focused on how the genomic studies are showing their posit.. Read More
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The mass spectral profiles of three major/emerging Gram positive pathogens belonging to the genera Clostridium, Listeria and Propionibacterium were investigated using four MALDI-TOF (Matrix-Assisted Laser Desorption/ Ionization- Time of Flight) Mass Spectrometers from Waters, Shimadzu, Bruker and Ciphergen Biosystems. These inst.. Read More
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Background: Bioanalytical laboratories in developing countries face many challenges. The objective of this work was to assess the capacity of bioanalytical laboratories in emerging countries in setting and validating analytical methods. An HPLC method for determination of lumefantrine in human plasma was used to assess thre.. Read More
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Poly (N-Isopropylacrylamide) Microgel-Based Etalons for Optical Sensing
Poly (N-isopropylacrylamide) (pNIPAm) is one of the most completely studied “smart” polymers due to its unique reversible thermoresponsivity. That is, when pNIPAm in water is heated > ~31°C, it transits from a random coil to a globule conformation; this transition is reversed when T < ~31°C. This confor.. Read More
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