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Studies were conducted on the Metabolism of sulfonylurea drug glyburide (5-chloro-N-(4-[N-(cyclohexylcarbamoyl) sulfamoyl] phenethyl)-2-methoxybenzamide) in human, mouse, rat, dog and monkey hepatic microsomes. Liquid chromatography with Diode array detector (LC-DAD) hyphenated with Q-Trap-Mass Spectrometer (Q-TRAP-MS/ MS) was e.. Read More
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For the last fifty years nuclear magnetic resonance spectroscopy, generally referred as NMR, is one of the most versatile techniques for elucidation of structure of organic compounds. Among all available spectrometric methods, NMR is the only technique which offers a complete analysis and interpretation of the entire spectr.. Read More
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A simple, precise, rapid, selective, and economic reversed phase high-performance liquid chromatography (RPHPLC) method has been established for estimation analysis of DRO. A Brownlee ODS C-18 column (250×4.6 mm i.d) chromatographic column equilibrated with mobile phase methanol-0.02 M KH2PO4 (80:20, v/v) (Final pH adjuste.. Read More
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A simple, precise, rapid, selective, and economic reversed phase high-performance liquid chromatography (RPHPLC) method has been established for simultaneous analysis of PRG and MC. A Phenomenex C18 (250×4.6 mm i.d) chromatographic column equilibrated with mobile phase water: methanol (60:40 v/v) adjusted to pH 6.5 with Tr.. Read More
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One of the biggest concerns with quantitative analysis of dried blood spots (DBS) is the uncertainty related to sample volume from a predefined punch. Blood with a high hematocrit will not diffuse as far as blood with a lower hematocrit when spotted on filter paper, resulting in differences in sample volume per unit area. Quanti.. Read More
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Objective: TLC densitometric method for quantification of gallic acid, quercetin and lupeol using HPTLC is developed. This is the first report of quantification of these three bioactive compounds viz. Gallic acid, quercetin and lupeol using HPTLC from this plant. Methodology: Quantification of gallic acid and quercetin was car.. Read More
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Is the Low-Resolution Mass Spectrometer Capable of Detecting Cancer at Early Stages?
It is known that cancer promotes changes in the metabolites found in biofluids and, therefore, the early detection of these metabolites allows for the best prognosis of the disease. Since ESI-MS fingerprinting has proved to be an excellent tool for ‘‘first pass’’ metabolome analysis of complex biolog.. Read More
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A Comparison of Red Pigments in Different Lipsticks Using Thin Layer Chromatography (TLC)
The main aim of present work is chromatographic analysis of red pigment in different well known and local brands of lipsticks. Lipstick samples of different brands of similar color were selected for this study. Coloring agent was analyzed by thin layer chromatography (TLC). Using different solvent systems [Toluene/Benzene] (4:12.. Read More
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The cellulose rich Roselle stem fiber found in abundance throughout the world was graft copolymerized by vinyl monomeric mixtures. The graft copolymer were characterized for the change in chemical structure by modern analytical techniques and evaluated for change in physical, chemical, thermal properties. These graft copolymers .. Read More
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A simple, rapid, precise and highly accurate RP-HPLC method was developed and validated for determination of alpha-mangostin content extracted from PLGA-microspheres. Method was developed using a silica-based deactivated C-18 column (4.6×100 mm, 3 μm) with a mobile phase of 70-80 % v/v acetonitrile (A) and 0.1% v/v orth.. Read More
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Here, we report a rapid and efficient liquid chromatographic method with UV detection for the simultaneous determination of rosuvastatin, alprazolam and diclofenac sodium in API, pharmaceutical formulations and human serum employing a reversed phase Bondapak C18 (25 cm, 0.46 cm, 10 μm) column at room temperature using methano.. Read More
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A simple, precise, accurate, and stability-indicating method is developed and validated for analysis of formoterol fumarate and mometasone furoate in metered dose inhalation formulations. Separation was achieved on a reversed-phase C18 column (150 mm×4.6 mm i.d., 5 μm) using a mobile phase consisting of Sodium dihydroge.. Read More
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A stability indicating HPLC assay with UV detection was developed for the simultaneous quantification of Gentamicin Sulfate and L-leucine from NanoGENT™ dry powder for inhalation. In order to support the development of the NanoGENT™ (dry powder gentamicin sulfate for inhalation) the assay was created to allow simulta.. Read More
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A novel,safe and sensitive method of spectrophotometric estimation in UV-region has been developed for the assay of Paracetamol in its tablet formulation. The method have been developed and validated for the assay of Paracetamol using Methanol and water as diluents. Which does not shows any interference in spectrophotometric est.. Read More
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Development and Validation of a Simple Method for the Detection of Fascaplysin in Plasma
Fascaplysin is a cytotoxic natural product isolated from a variety of Indo-Pacific marine organisms, primarily Fascaplysinopsis sponges and Didemnum tunicates. Positive xenograft studies involving this alkaloid structural class have indicated that fascaplysin may serve as an important lead compound for preclinical development. T.. Read More
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Charge Transfer Spectrophotometric Determination of Zolmitriptan in Pure and Dosage Forms
A facile, accurate, sensitive and validated spectrophotometric method for the determination of zolmitriptan (ZMT) in pure and dosage forms is described. The methods are based on the formation of charge transfer reactions between ZMT and chromogenic reagents 7,7,8,8-tetracyanoquinodimethane (TCNQ); p-chloranilic acid (P-CLA), qui.. Read More
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XRD Elaborates the Metamorphosis in Graft Copolymers
Sereni is present in abundance through-out the world. Its stem fiber has high tensile strength and low density that promotes it to serve as a backbone for graft-copolymerization. This cellulosic fiber was graft copolymerized by binary vinyl monomeric mixture using ceric ammonium nitrate-nitric acid as initiator system. The graft.. Read More
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A sensitive and selective high performance liquid chromatography method (HPLC) for simultaneous analysis of following five flavonoids like Gallic acid (GA), Caffeic acid (CA), Rutin (RU), Ferulic acid (FA) and Quercetin (QU) in Amaranthus caudatus (Sirukeerai) leaves. The results demonstrated that the Amaranthus caudatus leaves .. Read More
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Using the Advanced Analytical Techniques to Investigating the Versatile Cellulosic Graft copolymers
In this research paper, the cellulose rich biomass of Sorrel was graft copolymerized by vinyl monomeric mixtures. The graft copolymers were characterized by advanced analytical techniques like FTIR, SEM, XRD, TGA and DTA techniques and evaluated for physico-chemical changes in the properties of the modified fiber. With increase .. Read More
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Optimization of Chitin Extraction from Chicken Feet
The objective of present paper is to find optimal conditions for the extraction of chitin from chicken feet, so a chemical processing has been applied, to remove calcium carbonate (demineralization) and proteins (deproteinization). The optimum conditions included an acid concentration of 1.5 N, solid to acid ratio of 1:18 (w:v) .. Read More
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