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Analytical Method for Transdermal Delivery of the Anti-angiogenic Compound TNP-470
Pathological angiogenesis is a critical component in cancer, in chronic systemic inflammatory diseases such as psoriasis and rheumatoid arthritis, and in ocular diseases. Anti-angiogenic drugs have the ability to prevent, inhibit, and regress newly formed blood vessels. The activity of TNP-470 (chloro acetylcarbamoylfumagill.. Read More
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Evaluation of a Methodology for Automated Cell Counting for Streak Mode Imaging Flow Cytometry
Identification of Circulating Tumor Cells (CTCs) has shown promising clinical applications, but since CTCs are found in very low concentration in blood large sample volumes are needed for meaningful enumeration. This issue impedes the analysis of CTCs using standard flow cytometry due to its low throughput. To address this issue.. Read More
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A new method has been introduced based on aerosol hygroscopic growth as a new factor for trace and ultra-trace determination of phosphorous in flame containing optical trapping-cavity ring down aerosol extinction (emission) spectrometer (OT-CRD-AES). In this study, a cavity ring down has been designed using hydrogen and air as f.. Read More
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Monitoring Glycosylation Profile and Protein Titer in Cell Culture Samples Using ZipChip CE-MS
Rapid and sensitive product quality analysis is important for real-time monitoring during biopharmaceutical development and manufacturing. However, low level of protein concentration and complex cell culture matrix pose challenges for product quality characterization at early stages of cell line selection and process developme.. Read More
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The need of a robust, sensitive HPLC method for the quantitation of 6-thioguaninenucleotides (6-TG) and 6-methylmercaptopurine (6-MMP) is indispensable to relate levels of these metabolites with emergence of signs of toxicity in patients undergoing treatment with 6-mercaptopurine (6-MP), paving the road to accurate dose calc.. Read More
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Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water .. Read More
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Molecular Docking: Approaches, Types, Applications and Basic Challenges
Abstract Molecular docking is a kind of bioinformatic modelling which involves the interaction of two or more molecules to give the stable adduct. Depending upon binding properties of ligand and target, it predicts the three-dimensional structure of any complex. Molecular docking generates different possible adduct struct.. Read More
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Rapid Comparison of UVB Absorption Effectiveness of Various Sunscreens by UV-Vis Spectroscopy
Sunscreens are used to absorb or block harmful sunlight especially ultra violet (UV) radiation. An UV-vis spectrometer was employed to measure absorbance of sunscreen products. The same brand’s sunscreens with sun protection factor (SPF) of 8, 15, 30, and 50 were tested under identical experimental conditions. The re.. Read More
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Sensitive LC-MS/MS (Liquid Chromatography Tandem Mass Spectrometric) Method for the Simultaneous Determination of Alogliptin and Voglibose in human plasma. A highly sophisticated and sensitive LC-MS/MS method has been developed and validated for the Alogliptin and Voglibose simultaneous determination in human plasma. Al.. Read More
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Sub-Acute Toxicity Studies of Alchornea cordifolia Leaf Extract in Swiss Albino Rats
The ethanolic leaf extract of Alchornea cordifolia (Schum. and Thonn.) Müll. Arg (Euphorbiaceae), a widely used traditional medicinal plant was assessed for possible sub-acute toxicity in Swiss albino rats. The rats were randomly distributed into five groups of four animals each. The groups were respectively administered 12.. Read More
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A Novel Methodology for the Quantification of B-Vitamers in Breast Milk
With this report we present development, validation and application of an analytical methodology for the quantification of 18 water soluble vitamers and secreted or biological forms in breast milk. On a relatively low amount of breast milk (200 µL), we applied isotope dilution-based sample preparation based on a com.. Read More
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In this study, a novel approach is proposed for determination of methylphenidate in biological fluids. In this method molecularly imprinted solid-phase extraction (MISPE), as the sample extraction technique, combined with high-performance liquid chromatography (HPLC) is used. The water-compatible molecularly imprinted polymers (.. Read More
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A screen-printed electrode based on a graphite and polyurethane composite (SPGPU) was used in the determination of epinephrine (EP) in cerebral synthetic fluid (CSF) sample. Both Differential Pulse Voltammetry (DPV) and Square Wave Voltammetry (SWV) were used to investigate the suitability of sensor for determination of EP. Un.. Read More
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For over a century, research on cannabis has been hampered by its legal status as a narcotic. The recent legalization of cannabis for medical purposes in North America requires rigorous standardization of its phytochemical composition in the interest of consumer safety and medicinal efficacy. To utilize medicinal cannabis as a p.. Read More
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Photocatalytic Studies of Tio2/Sio2 Nanocomposite Xerogels
The use of titania-silica materials in photocatalytic processes has been proposed as an alternative to the conventional TiO2 catalysts, in order to facilitate the separation of products after the reaction. However, despite the large number of research in this field, the mechanism governing the photocatalytic activity of the mi.. Read More
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The research demonstrates the significance of some physicochemical parameters on the screening characteristics of suspension in bioremediation sampling. In this investigation, physicochemical parameters of soil sample polluted with crude oil was subjected into sampling by considering the total phosphorus, nitrogen and pH con.. Read More
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Study of Breath Acetone in a Rat Mode of 126 Rats with Type 1 Diabetes
We investigate correlations of breath acetone with blood glucose (BG) and blood beta-hydroxybutyrate (BHB) in a rat model of 126 streptozotocin-induced Type 1 diabetic (T1D) and 32 healthy rats, and evaluate the role of breath acetone analysis as a non-invasive alternative in diabetes screening and management. We conducted breat.. Read More
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Dashmula are specific ayurvedic combination of ten roots used for various disorders of liver, kidney, uterus. Standardisation of herbals are necessity for efficacy and quality parameter as per WHO guidelines. Therefore, through this original research attempt was made to standardise one of ‘Dashmula’, P. integrifolia .. Read More
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A Comparison Between Two Assays for the Redox Status in Plasma
In the present study, two commercial assays for the redox status are compared and evaluated, the SH groups in proteins (SHp) and the total thiol levels (TTL). Both assays are colorimetric endpoint reactions and have been adapted for use on an automatic clinical analyzer. Both assays performed well by giving comparable result.. Read More
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Herbal Hair Gel Formulation having 5α-Reductase Inhibitory Activity and its Standardization by HPTLC
The present work has been undertaken with the aim to formulate hair growth gel formulation containing extracts of Hibiscus rosa sinensis flower 1%, Eclipta alba whole plant 1% and Solanum nigrum plant berries 0.5% which are preferably used in case of Alopecia, i.e., baldness pattern as an effective herbal therapy showing 5 &al.. Read More
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