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Advancements in the Treatment of Pancreatic Cancer, the Most Prevalent Condition Diagnosed
The incidence of pancreatic cancer is predicted to keep rising, making it one of the main causes of cancer death. Although individuals with pancreatic cancer have often had a poor prognosis, recent improvements in detection and therapy have started to have a favourable influence on this illness. Although there are still worries .. Read More
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A Short Note on Role of Exosomes in Cancer
Exosomes are extremely tiny extracellular vesicles that are widely dispersed in a variety of bodily fluids and are released by several cell types. Exosomes may help control the tumour microenvironment and have an effect on the growth and spread of tumours, according to recent studies. Exosomes have come into attention in the hun.. Read More
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Pericarditis is a frequent condition with several causes that can manifest in both primary and tertiary care settings. It is identified in 5% of emergency room visits for chest discomfort and 0.1% of all hospital admissions. Even if new diagnostic methods have advanced, Radiation therapy, heart surgery, and percutaneous coronary.. Read More
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Review of Breast Cancer and the Implications of Programmed Cell Death
Cell death is an inevitable part of life and is essential for controlling disease situations, ageing, and organismal growth. Cell death can occur in both controlled and unregulated ways. In recent years, programmed cell death (PCD)-induced cell death has drawn more and more attention. The improper regulation of PCD is crucial to.. Read More
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Renal cell carcinoma (RCC), with 400,000 diagnoses and 180,000 deaths in 2020, represents 2.4% of all cancer diagnoses globally industrialised nations with the greatest rates of sickness, particularly in Europe and North America.As more nations adopt Western lifestyles, incidence is expected to rise in the future. In addition to.. Read More
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One of the etiological causes for gallbladder cancer may be H. pylori infection in gallbladder
One of the most prevalent chronic bacterial illnesses is known as helicobacter pylori. In addition to being the primary pathogenic agent in chronic gastritis, peptic ulcers, and gastric cancer, it has also been suggested as the etiological factor in illnesses of organs other than the stomach and duodenum, such as the liver, bili.. Read More
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High Intermediate Risk (HIR) Features in Early Stage Endometrial Carcinoma (EC)
Statin usage has been shown to reduce the incidence and increase survival of gynecologic malignancies, although its effect on endometrial carcinoma (EC) is still unclear. Our main goal is to look at statin usage and its correlation with early-stage EC characteristics associated with high intermediate risk (HIR). Our hypothesis i.. Read More
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Purpose: Venous Thromboembolism is a common and frequent complication seen in active cancer patients. The Khorana Risk Score (KRS) is a simple model which helps to guide selection of high risk VTE cancer patients for thromboprophylaxis. However very little information is available on Khorana score validation in low middle income.. Read More
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ABC-Mediated Multidrug Resistance Brought on by Therapy in PC-3 Prostate Cancer
Background: The number of deaths from prostate cancer is still high due to ATP Binding Cassette (ABC)-Mediated Multidrug Resistance (MDR). Overexpression of ABC transporters causes multidrug resistance in most prostate cancer chemotherapies. P-glycoprotein (P-gp) is one of the common drug transporters associated with MDR. There .. Read More
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Seaweed, coral, and sponges are examples of sessile creatures that constantly adapt to the biotic and abiotic elements of the ecosystem. To maintain an ecological niche suited for life, this incredibly intricate and dynamic process frequently leads to various types of competition. As a defensive strategy against the outside envi.. Read More
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For several years now, the therapeutic situation in the management of non-small cell lung cancer using the immunotherapy protocol has allowed the approval of several drugs. These different drugs have shown fantastic results but with the downside of some side effects whether in monotherapy or in dual therapy with chemotherapy or .. Read More
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The Role of Sulforaphane on Duchenne Muscular Dystrophy by Activation of Nrf2
Sulforaphane (SFN) possesses powerful chemo-preventive effects and plays a crucial role on oxidative stress and inflammatory. In our recent study, SFN treatment could relieve muscular dystrophy in mdx mice by activating Nrf2 (NF-E2 related factor 2). Moreover, our findings indicated that SFN-activated Nrf2 alleviated muscle infl.. Read More
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Introduction: There are numerous radiographic scoring methods in Rheumathoid Arthritis (RA). The scoring method Sharp/van der Heijde (SHS) is considered “a gold standard” for the assessment of the disease progression in RA. It is reliable but complex scoring method, which is time consuming and is used by well trained.. Read More
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Determination of the Carpal Unstability in Patients with Rheumatoid Arthritis
Introduction: The carpal instability is a biomechanical alteration with multiple pathogenesis. It ensues due to disturbance of the normal ligament and bone connections that control the wrist. There are four major types of carpal instability: 1 Dorsal intercalated segment instability (DISI) 2.Volar intercalated segment instabilit.. Read More
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Minocycline Attenuates Severe Hyperglycemia in Patient with Lipodystrophy
Context: Familial partial lipodystrophy (FPL) may appear with metabolic perturbations that include acute insulin resistance and severe hyperglycemia with poor metabolic control despite extremely high doses of insulin. Objective: We report on a patient with FPL, insulin resistance, and hyperglycemia (fasting glucose >180- 200.. Read More
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Immune Reconstitution Inflammatory Syndrome (IRIS) in a Child with Disseminated Tuberculosis
IRIS is a paradoxical reaction occurring in HIV-infected patient after initiation of highly active antiretroviral therapy (HAART). Incidence is estimated 12 to 19% of child starting HAART. IRIS with tuberculosis in non-HIV patients has not been reported in the literature. We report the case of an HIV negative 8 years-old girl wh.. Read More
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Naturally Occurring Enzyme Inhibitors: A Smart Way to Fight against Micro- Inflammation in Human Gut
Human body is a reservoir for microorganisms, the majority of which resides in the gastrointestinal tract. The diverse micro biota helps to speed up the metabolic processes such as digestion along with providing protection against infections. A balanced diet plays major role in maintaining the balance of gut flora, which could o.. Read More
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Bone Health in Metabolic Endotoxemia Related Obesity
Obesity is a multifactorial disorder leading to multiple metabolic complications including hypertension, hypercholesterolemia, atherosclerosis, insulin resistance, type II diabetes and fatty liver. Recent research has discovered that obesity is associated with systemic low grade inflammation and one of the contributing factors c.. Read More
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Lipid Lowering Therapy and Endothelial Function in Patients with Metabolic Syndrome
Introduction: Endothelial dysfunction (ED) plays an important role in the development and clinical manifestation of atherosclerosis. Endothelial dysfunction has been defined as the barometer of vascular health. Therefore, the development of reliable, safe, and noninvasive methods of endothelial function assessment is important f.. Read More
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Immunological Properties of Breast Milk: A Prospective Study in 589 Children
Background: Normal neonates are equipped with a limited immunocompetence, therefore they need breast milk (BM), which represent an excellent immune protection for the neonate during the critical period of intestinal vulnerability, due to a great variety of functionally interactive immunological, antibacterial, antiviral, anti-in.. Read More
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