therapeutic proteins are now established biologics, with high activity against many ocular diseases. However, design of novel drug delivery systems to achieve a non-toxic, constant and efficient delivery with minimal doses of therapeutic proteins is still challenging. Several factors, such as the protein aggregation, unfolding for improving bioavailability of protein to the retina, interactions of biologics with the retina, diffusion in the vitreous, penetration inside the retinal layers, and finally elimination from the eye needs to be carefully studied
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Last date updated on March, 2024