ISSN: 2476-2253
Journal of Cancer Diagnosis
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Breast Cancer Diagnosis
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Breast Cancer Diagnosis
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Breast Cancer Diagnosis
Breast cancer can be diagnosed by Mammogram and breast ultrasound- a technique using X-rays to diagnose and locate tumours of the breasts. Biopsy: biopsy and histological examination of the tissue. Magnetic resonance imaging (MRI) of the tissue. Tumour biomarkers: detection of biomarkers on cell surface like Estrogen receptor (ER) and progesterone receptor (PR), Human epidermal growth factor receptor 2 (HER2), Cancer antigen 15-3 (CA 15-3), cancer antigen 27.29 (CA 27.29), and carcinoembryonic antigen (CEA).
Related Journals of Breast Cancer Diagnosis
Journal of Cancer Diagnosis,Cancer Surgery Journal,Cancer Prevention Journal,Cancer Medicine Journal,Clinical Oncology Journal,Breast Cancer Research, Breast Cancer Research and Treatment, Breast Cancer: Basic and Clinical Research, Journal of Breast Cancer.
Breast Cancer Diagnosis
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Classically, the 3ââ¬â¢untranslated region (3ââ¬â¢UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3ââ¬â¢UTR alone, without all other elements in mRNA such as 5ââ¬â¢UTR and coding region. The importance of independent 3ââ¬â¢UTR RNA (referred as I3ââ¬â¢UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3ââ¬â¢UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3ââ¬â¢UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3ââ¬â¢UTR were important for its tumor suppression activity. Then, the C/EBP 3ââ¬â¢UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3ââ¬â¢UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3ââ¬â¢UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990ââ¬â¢s to 2000ââ¬â¢s, world scientists found several 3ââ¬â¢UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3ââ¬â¢UTR regions, although the existence of their transcribed products as independent 3ââ¬â¢UTR RNAs is still to be confirmed. Our studies indicate that the independent 3ââ¬â¢UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
PPT Version | PDF Version - Fan-Gang Tseng
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| PDF Version - Phillip K. Darcy
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PPT Version | PDF Version - Almas Okassov
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PPT Version | PDF Version - Alvaro Ronco
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PPT Version | PDF Version - Antonio Cilla
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PPT Version | PDF Version - Mirette Hanna
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PPT Version | PDF Version - Vineeta Deshmukh
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PPT Version | PDF Version - Mingsong Wu
Identification of differentially expressed genes in human lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene
PPT Version | PDF Version - Dean A
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PPT Version | PDF Version - Liselotte Jakobsson
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Na,K-ATPase isoform-selective cardiac glycosides- a potential anti-cancer drug ?
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PPT Version | PDF Version - RanjitaPallavi
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PPT Version | PDF Version - Daniel Rotroff
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| PDF Version - Mark Kester
Nanocolloidsfor Cancer
PPT Version | PDF Version - Yajun Yi
Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
PPT Version | PDF Version - Vladimir Pak
Double Targeting as an Effective Anti-Cancer Strategy
PPT Version | PDF Version - Luminita Castillos
Gene expression profiling for targeted cancer treatment
PPT Version | PDF Version - Anton Yuryev
Construction of cancer pathways for personalized medicine
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Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
| PDF Version - Maria Paola COSTI
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Stimuli-sensitive combination nanopreparations of siRNA and chemotherapeutic drugs to treat multidrug resistant cancer
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PPT Version | PDF Version - Zuping Xia
Development of Sphingosine Kinase Inhibitors for Cancer Therapy
PPT Version | PDF Version - Charles F. L. Mbakaya
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PPT Version | PDF Version - Makobetsa Khati
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PPT Version | PDF Version