Prion Diseases

"Current research in prion immunology has suggested the possible involvement of multiple cell types of the lymphoreticular system (LRS) during disease progression. Interestingly, almost all cells of the LRS express high levels of PrPCon their surface, which may be a reason why they are involved in the early stages of the disease. Prion accumulation has also been found within granulomas of transgenic mice infected with prions, in lymphoid follicles of kidneys in white-tailed deer infected with the CWD agent ,and has been identified at low levels within the muscle of mule deer infected with the CWD agent and in the muscle tissue of hamsters infected with the TME agent, potentially associated with local inflammation in those tissues .This clearly implicates a role for the immune system as a potential target, if not responder, to the prion agent (The Immune System in the Pathogenesis and Prevention of Prion Diseases: Furr A, et al.) OMICS Group is one of the top open access publishers with 700+ peer-reviewed journals along with eminent scientists in its Editorial Board and expert reviewers to carry rigorous peer-review process. The peer review process is highly appreciated by researchers globally. Editorial Board Members and Reviewers actively participate in the review process within 21 days and ensure the quality of the manuscripts. OMICS journals have great deal of information out there on scientific topics. However, whether it can be trusted or not is a key issue at present. One of the most acceptable and proven process adopted in majority reputed international journals is peer reviewing. "

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Last date updated on April, 2024