APE1 is a central enzyme of BER-pathway with primary two major independent cellular functions; repair and redox. Both functions are displayed by two different regions of the protein. Primarily, repair function through C-terminus, which involves removal of AP sites in DNA. Second function is reductive activation of several TFs displayed via disordered N-terminus which also possesses the Nuclear Localization Signal (NLS), controlling gene expression for significant cellular pathways. Because of redox activity, APE1 is also known as redox effector factor-1.
OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society.
Last date updated on April, 2024
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi