G-Quadruplexes

In the past few decades a large number of scientific papers, both computational and experimental in vitro and in vivo, have demonstrated that G-rich DNA sequences can fold as intrastrand quadruple helix structures called G-quadruplexes or G4-DNA. G4-DNA is stabilized by G-quartets, planar arrays of four guanines paired by Hoogsteen hydrogen bonding, and monovalent alkali cation, K+ or Na+, located in the central cavity of the structure. In the human genome the sites that can potentially form G4- DNA are estimated to be more than 3,00,000. They are not randomly distributed, but located preferentially in repetitive genomic sequences such as the telomeres, ribosomal DNA and the immunoglobulin heavy-chain switch regions. In the growing environment, they are many journals in various organisations. Only a very few journals maintain high standards in terms of the content they publish, one has to be careful while picking information as content that is not reliable and untrue can be harmful to research as well as society. Generally, journals can be rated by considering impact factor, reputation of authors, editorial board members and also in terms of the fee they charge. Only high indexing journals have quality articles. Molecular Biology is one of the best journals which publish quality articles. Molecular Biology is a wide range of area that deals with different aspects. It publishes original research, review, short communication, case report, mini review etc.

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Last date updated on April, 2024