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Liver biopsy is being performed to diagnose a condition that affects the entirety of the liver. Whether a patient has a chronic viral infection like chronic hepatitis B or C, or an autoimmune disease like primary biliary cirrhosis, or a metabolic disease like hereditary hemochromatosis, it is anticipated that the underlying disease process affects all regions of the liver equally.
The assessment of chronic viral hepatitis in liver biopsy specimens has become confusing with the proliferation of grading and staging schemes that have paralleled the rise of the hepatitis C epidemic and the importance of mixed viral infections.
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