Figure 1: Adiponectin, leptin and their effects in immune system and obesity. A. Adiponectin has an anti-inflammatory effect, promoting the reduction of inflammatory response as shown by several mechanisms. In obesity, adiponectin levels are low, promoting the acute phase of inflammation. B. Leptin has a proinflammatory effect, promoting the increase of inflammatory response. In obesity, leptin levels are high, suppressing or increasing some kind of T-cells populations, increasing the inflammatory response in adipose tissue.