| Research Article |
Open Access |
|
| Molecular Docking Studies of Curcumin Derivatives with
Multiple Protein Targets for Procarcinogen Activating Enzyme
Inhibition |
| C.R. Girija1*, Prashantha Karunakar1, Chetan S Poojari1, Noor Shahina Begum2 and Akheel Ahmed Syed3 |
| 1Department of Chemistry, SSMRV College, 4thT Block, Jayanagar, Bangalore-560041, India |
| 2Department of Studies in Chemistry, Bangalore University, Central College Campus, Bangalore-560001, India |
| 3Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India |
| *Corresponding author: |
C.R. Girija, Department of Chemistry,
SSMRV College,
4th T Block, Jayanagar,
Bangalore-560041, India,
Tel: +91 98864 19952,
E-mail: girijashivakumar@rediffmail.com |
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| Received May 25, 2010; Accepted June 26, 2010; Published June 26, 2010 |
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| Citation: Girija CR, Karunakar P, Poojari CS, Begum NS, Syed AA (2010)
Molecular Docking Studies of Curcumin Derivatives with Multiple Protein Targets
for Procarcinogen Activating Enzyme Inhibition. J Proteomics Bioinform 3: 200-
203. doi:10.4172/jpb.1000140 |
| |
| Copyright: © 2010 Girija CR, et al. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and
source are credited. |
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| Abstract |
| Curcumin derivatives which are very potent antioxidant, free radical scavenger and known inhibitor of dioxygenases have been extensively studied to explore their potential utilization in chemoprevention. The main objective of the present work is to perform a docking analysis of curcumin derivatives: Tetrahydrocurcumin (THC), Bisdemethoxy curcumin (BDC). Docking studies of these were performed using GOLD and AutoDock into a few well validated targets of anticancer therapy (COX-2, PhenolsulphoTransferases, Matrix metalloproteinases (MMPs), P450 and TNF-alpha). A good correlation was observed in binding affi nity of THC and BDC against the targets indicating these derivatives are potent procarcinogen activating enzyme inhibitors. |
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