| Research Article |
Open Access |
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| SERPINE 1 Links Obesity and Diabetes: A Pilot Study |
| Punit Kaur1, Michael D. Reis2, Glen R. Couchman2, Samuel N. Forjuoh2, John F. Greene Jr1 and Alexzander Asea1* |
| 1Department of Pathology, Scott & White Memorial Hospital and Clinic, and the Texas A&M Health Science Center, Temple, TX 76504 USA |
| 2Department of Family & Community Medicine, Scott & White Memorial Hospital and Clinic, and the Texas A&M Health Science Center, Temple, TX 76508 USA |
| *Corresponding author: |
Dr. Alexzander Asea,
Chief Division of Investigative
Pathology,
Scott & White Memorial Hospital and Clinic,
and the Texas A&M Health
Science Center,
Temple,
TX 76508 USA,
Tel: +1-254-743-0201,
Fax: +1-254-743-
0247,
E-mail: asea@medicine.tamhsc.edu, aasea@swmail.sw.org |
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| Received May10, 2010; Accepted June 16, 2010; Published June 16, 2010 |
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| Citation: Kaur P, Reis MD, Couchman GR, Forjuoh SN, Greene JF Jr, et al. (2010)
SERPINE 1 Links Obesity and Diabetes: A Pilot Study. J Proteomics Bioinform 3:
191-199. doi:10.4172/jpb.1000139 |
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| Copyright: © 2010 Kaur P, et al. This is an open-access article distributed under
the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and
source are credited. |
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| Abstract |
| In the past decade there has been a dramatic increase in the number of Americans considered obese. Over this
same period, the number of individuals diagnosed with diabetes has increased by over 40%. Interestingly, in a great
number of cases individuals considered obese develop diabetes later on. Although a link between obesity and diabetes
has been suggested, conclusive scientific evidence is thus far just beginning to emerge. The present pilot study
is designed to identify a possible link between obesity and diabetes. The plasma proteome is a desirable biological sample
due to their accessibility and representative complexity due, in part, to the wide dynamic range of protein concentrations,
which lead to the discovery of new protein markers. Here we present the results for the specific depletion of 14 high-abundant
proteins from the plasma samples of obese and diabetic patients. Comparative proteomic profiling of plasma
from individuals with either diabetes or obesity and individuals with both obesity and diabetes revealed SERPINE 1 as
a possible candidate protein of interest, which might be a link between obesity and diabetes. |
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