Pharmaco-Informatics: Homology Modelling of the Target Protein
(GP1, 2) for Ebola Hemorrhagic Fever and Predicting an
Ayurvedic Remediation of the Disease |
| Preenon Bagchi*, Mahesh. M, Somashekhar.R |
| Azyme Biosciences, #1188/20, 3rd Floor, 26th Main, Jayanagar 9th Block, Bangalore-560069, India |
| *Corresponding author: |
Dr. Preenon Bagchi, Azyme Biosciences, #1188/20, 3rd Floor, 26th Main,
Jayanagar 9th Block, Bangalore-560069, India,
E-mail: preenonb@yahoo.com |
|
| Received February 24, 2009; Accepted April 15, 2009; Published July 07, 2009 |
Citation: Bagchi P, Mahesh M, Somashekhar R (2009) Pharmaco-Informatics: Homology Modelling Of The Target Protein
(GP1, 2) For Ebola Hemorrhagic Fever And Predicting An Ayurvedic Remediation Of The Disease. J Proteomics Bioinform
2: 287-294. doi:10.4172/jpb.1000088 |
Copyright: ©2009 Bagchi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited. |
| Abstract |
Ebola hemorrhagic fever (Ebola HF) is caused by infection with Ebola Virus. Ebola virus, a member of the
family Filoviridae, causes one of the most severe forms of viral hemorrhagic fever. In the final stages of the
disease, symptoms progress to hypotension, coagulation disorders, and hemorrhages, and there is prominent
involvement of the mononuclear phagocytic and reticulo-endothelial systems. It is assumed that the functions of
the envelope glycoprotein are likely to play important roles in the pathogenicity of Ebola virus and the interactions
of some viral proteins with the immune system are likely to play important roles in the extraordinary
pathogenicity of this virus. Ebola virus (EBOV) entry requires the surface glycoprotein (GP) to initiate attachment
and then fusion occurs between viral and host membranes. All glycoprotein forms are encoded by gene 4
of the EBOV genome. The strain selected is VGP_EBOSU with accession number Q7T9D9 of Sudan Ebola
Virus - Uganda (2000) from NCBI’S entrez database. The 3D structure of Ebola Virus Protein was generated
using Homology Modelling. For a predicted evaluation Andrographolide is used (the compound needs clinical
trials to prove its efficacy in treatment). The 3D structure of Andrographolide was generated and was converted
to *.pdb file which now docks with the *.pdb file of Ebola Virus Protein. |
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