Study of Microsatellites Role in BRCA2 Gene Causing Pancreatic Cancer and
Breast Cancer
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Allam Appa Rao1, Sridhar R Gumpeny2, MN Vamsi Thalatam*1,3, S Sita Ram Babu1, N Ravi Shankar1, P Anuradha1 |
| 1Department of Computer Science and Systems Engineering, Andhra University,
Visakhapatnam-530003, India |
| 2Endocrine and Diabetes Center, Krishnanagar, Visakhapatnam-530002, India |
| 3GVP College for Degree & PG Courses, Visakhapatnam, 530045, India |
| *Corresponding author: |
Dr. MN Vamsi Thalatam,
E-mail: enireddy.vamsidhar@gmail.com |
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| Received April 20, 2008; Accepted May 15, 2008; Published May 25, 2008 |
| Citation: Appa RA, Sridhar RG, Vamsi TMN, Ram Babu SS, Ravi SN, etal. (2008) Study of Microsatellites Role in BRCA2
Gene Causing Pancreatic Cancer and Breast Cancer. J Proteomics Bioinform S1: S038-S040. doi:10.4172/jpb.s1000006 |
| Copyright: ©2008 Allam AR, etal. This is an open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author
and source are credited. |
| Abstract |
BRCA2 gene plays an important role in the development of pancreatic cancer. Diabetics may have a slightly increased risk of
pancreatic cancer. Previous literature reveals that the Mutations in these genes are also causing the breast cancer. A detailed
bioinformatics study of all the known mutations in the BRCA2 gene revealed interesting information. The information of all the
experimentally proven mutations were collected and analyzed using bioinformatics tools and software programs. We tried to
find out whether the presence of microsatellites or simple sequence repeats in the BRCA2 gene has any significance in the
generation of these mutations. Our analysis revealed that there are 161 mutations available (HGMD) in BRCA2 gene under
missense/nonsense Category. We report that none of these 161 mutations fall inside the microsatellite tracts and thus indicating
no role of microsatellites in BRCA2 gene. |
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