Identification of a Point Mutation Causing Splitting of Antigenic Domain in M1 Protein
of H5n1 Strain from 2006 Outbreak in India |
| Tamanna Anwar, Asad U Khan |
| Interdisciplinary Biotechnology Unit Aligarh Muslim University, Aligarh 202002 India |
| Corresponding author: |
Dr Asad U Khan, Lecturer, Interdisciplinary Biotechnology Unit,
AMU,
Aligarh 202002 India,
Phone:091-571-2723088;
Fax:091-571-2721776;
E-mail: huzzi99@hotmail.com |
|
| Received August 01, 2008; Accepted September 08, 2008; Published September 13, 2008 |
| Citation: Tamanna A, Asad UK (2008) Identification of a Point Mutation Causing Splitting of Antigenic Domain in M1
Protein of H5n1 Strain from 2006 Outbreak in India. J Proteomics Bioinform 1: 302-306. doi:10.4172/jpb.1000038 |
| Copyright: ©2008 Tamanna A, etal. This is an open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original
author and source are credited. |
| Abstract |
Influenza virus shows great variation in virulence. Numerous influenza virulence studies have sought to define the roles of
each viral gene in disease production.To understand M1 protein it is necessary to study the functional properties of its distinct
domains. Until now, in silico studies on M1 protein of Influenza A H5N1 virus are limited. The purpose of this study was to
analyze the antigenic domains of the M1 protein of H5N1 strains found epidemic in Navapur (ABG88883) and Jalgaon, India
(ABJ96491) during 2006 outbreak, and to identify antigenic differences between M1 proteins of other strains from different
origin. It was noticed that the splitting of antigenic domain within position 48 to 69 of M1 was due to point mutation at position
59 from Isoleucine to Methionine. The antigenic regions identified here might be important for the development of diagnostic
test for Influenza A H5N1 infection showing discrimination between different antigenic types of M1 protein of Influenza A
H5N1. |
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