Comparison of the Virulence Factors and Analysis of Hypothetical
Sequences of the Strains TIGR4, D39, G54 and R6 of Streptococcus Pneumoniae |
R. Jothi, S. Parthasarathy*, K. Ganesan |
| Department of Bioinformatics, School of Life Sciences Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India |
| *Corresponding author: |
Dr. S. Parthasarathy, Department of Bioinformatics,
School of Life Sciences, Bharathidasan University,
Tiruchirappalli 620 024,Tamil Nadu, India,
Phone: +91 94435 33095,
Fax: +91 431 2407045,
E-mail: bdupartha@gmail.com |
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| Received October 21, 2008; Accepted November 19, 2008; Published December 26, 2008 |
| Citation: Jothi R, Parthasarathy S, Ganesan K (2008) Comparison of the Virulence Factors and Analysis of Hypothetical Sequences of the Strains TIGR4, D39, G54 and R6 of Streptococcus Pneumoniae . J Comput Sci Syst Biol 1: 103-118. doi:10.4172/jcsb.1000010 |
| Copyright: ©2008 Jothi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Abstract |
Whole genome sequences of the four strains of Streptococcus pneumoniae, encapsulated TIGR4, D39, G54 and
nonencapsulated R6 are considered for the comparative study on genome features, whole genome pairwise
alignment, gene role category, and virulence factors using relevant comparative genomics tools. The study of
capsular polysaccharide synthesizing genes reveals that many cps genes are unique to TIGR4, which shows the
high virulence nature of TIGR4. Further, the study on the other virulence factors such as pneumococcal surface
protein A, autolysin, hyaluronate lyase, pneumolysin, neuraminidase B, and pneumococcal surface antigen A of
TIGR4 are much related to those of the other three strains, and hence the virulence nature due to these factors
among four strains seems to be similar. But it differs from neuraminidase A, choline binding protein A and
immunoglobulin A1 protease. Also in the present study, 4 and 22 hypothetical protein sequences of TIGR4 and
R6 respectively are predicted as virulence factors. Among those sequences, it is found that 8 hypothetical
protein sequences with 7 different functional regions of R6 are related to other previously known virulence
factors of TIGR4 and R6 of S. pneumoniae. |
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